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Additionally, material property changes with thermoforming were studied to elucidate its role in material performance in\u2010vitro. An orthodontic simulator (OSIM) was used to evaluate forces and moments at 0.20\u2009mm of lingual displacement for central incisor, canine and second premolar using Polyethylene terephthalate (PET), Polyurethane (PU) and Glycol\u2010modified polyethylene terephthalate (PET\u2010G) materials. The OSIM was scanned to generate a model used to fabricate aligners using manufacturer\u2010specified thermoforming procedures. Repeated measures of MANOVA was used to analyze the effect of teeth and material on forces\/moments. The role of thermoforming was evaluated by flexural modulus estimated by 3\u2010point bend tests. Pre\u2010thermoformed and post\u2010thermoformed samples were prepared using as\u2010received sheets and those thermoformed over a simplified arch using rectangular geometry, respectively. Groups were compared using Two\u2010way ANOVA. The PET, PU, and PET\u2010G materials exerted maximum buccal force and corresponding moments on the canine. PU exerted more buccal force than PET\u2010G on the canine and second premolar, and more than PET on the second premolar. The impact of thermoforming varied according to the specific polymer: PET\u2010G remained stable, there was a slight change for PET, and a significant increase was noted for PU from pre\u2010thermoformed to post\u2010thermoforming. The results of this study elucidate the influence of material and arch position on the exerted forces and moments. Further, the mechanical properties of thermoplastic materials should be evaluated after thermoforming to characterize their properties for clinical application.<\/jats:p>","DOI":"10.1002\/jbm.b.35145","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T06:44:31Z","timestamp":1660113871000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Investigating the role of aligner material and tooth position on orthodontic aligner biomechanics"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-9505","authenticated-orcid":false,"given":"Harsimrat","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Dentistry University of Alberta  Edmonton Alberta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsolmonbaatar","family":"Khurelbaatar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Alberta  Edmonton Alberta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mah","sequence":"additional","affiliation":[{"name":"School of Dental Medicine University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giseon","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Alberta  Edmonton Alberta USA"},{"name":"Department of Dentistry and Dental Hygiene University of Alberta  Edmonton Alberta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Major","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Alberta  Edmonton Alberta USA"},{"name":"Department of Dentistry &amp; Dental Hygiene, Division of Orthodontics University of Alberta  Edmonton Alberta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan L.","family":"Romanyk","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Alberta  Edmonton Alberta USA"},{"name":"Department of Mechanical Engineering University of Alberta  Edmonton Alberta USA"},{"name":"Department of Mechanical Engineering and School of Dentistry University of Alberta  Edmonton Alberta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"385","article-title":"The vacuum formed dental contour appliance","volume":"30","author":"Nahoum HI","year":"1964","journal-title":"N Y State Dent J"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0096-6347(45)90101-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12480"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12353"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2319\/061614-436.1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2319\/052512-432.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-015-0307-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2319\/033009-181.1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjq007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.08.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2014.03.015"},{"key":"e_1_2_8_13_1","unstructured":"Van Alfen N. 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