{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:25:22Z","timestamp":1781285122835,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV NU21\u201006\u201000370"],"award-info":[{"award-number":["AZV NU21\u201006\u201000370"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007059","name":"Univerzita Palack\u00e9ho v Olomouci","doi-asserted-by":"publisher","award":["IGA_PrF_2022_023"],"award-info":[{"award-number":["IGA_PrF_2022_023"]}],"id":[{"id":"10.13039\/501100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This unique study provides information on Cr species and their distribution in periprosthetic tissues of patients with metal\u2010on\u2010polyethylene joint implants. Co\u2013Cr\u2013Mo alloy has been widely used in joint replacement and represents a source of metal derived species. In the case of chromium, previous studies on periprosthetic tissues revealed mainly Cr(III) distribution, whereas the potential release of carcinogenic Cr(VI) species has been still a subject of debate. Here, an analytical approach utilizing speciation and fractionation was developed to analyze periprosthetic tissue samples collected from wide range of patients with failed total hip or knee replacements. The results reveal that Cr(III) is mainly released in the form of insoluble CrPO<jats:sub>4<\/jats:sub> and Cr<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> particles. The highest Cr contents were found in periprosthetic tissues of patients suffering from aseptic loosening and having more Cr\u2010based implants in the body. Cr species penetrated tissue layers, but their levels decreased with the distance from an implant. The detailed speciation\/fractionation study carried out using the set of consecutive periprosthetic tissues of a patient with extensive metallosis showed the presence of trace amounts of free Cr(III), nanoparticles, and metal\u2010protein complexes, but the majority of Cr still occurred in CrPO<jats:sub>4<\/jats:sub> form. Carcinogenic Cr(VI) species were not detected. Up to date, there is no published human tissue study focused on the detailed speciation of both soluble and insoluble Cr\u2010based species in the context of failing total hip and knee replacements.<\/jats:p>","DOI":"10.1002\/jbm.b.35149","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T09:25:44Z","timestamp":1660728344000},"page":"271-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Detailed insight into chromium species released from failed <scp>CoCrMo<\/scp> implants: Ex vivo periprosthetic tissues study"],"prefix":"10.1002","volume":"111","author":[{"given":"Radka","family":"Pechancov\u00e1","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine and Dentistry Palack\u00fd University Olomouc, University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-6728","authenticated-orcid":false,"given":"David","family":"Milde","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Slobodov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Lemr","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"},{"name":"Institute of Microbiology of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-0016","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Pluh\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Science Palack\u00fd University Olomouc  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.01.001"},{"key":"e_1_2_10_3_1","unstructured":"UZIS.Narodni registr kloubnich nahrad.2020."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13092011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wear.2021.203813"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.05.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.027"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jbm.b.34137","article-title":"Content of distinct metals in periprosthetic tissues and pseudosynovial joint fluid in patients with total hip arthroplasty","volume":"107","author":"Kuba M","year":"2018","journal-title":"J Biomed Mater Res B"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.03.100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1243\/09544119JEIM112"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B4.36767"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"Handbook of elemental speciation II species in the environment","author":"Cornelis RC","year":"2004","journal-title":"Food Med Occup Health Chichester"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2017.12.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sab.2018.12.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11225-w"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc33016d"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.06.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/190\/1\/012208"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S139262"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115888"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820290510"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470868384"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2016.02.035"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00527-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121150"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121538"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c004508j"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/es403558c"},{"key":"e_1_2_10_29_1","first-page":"416","article-title":"The number of lymphocytes increases in the periprosthetic tissues with increasing time of implant service in non\u2010metal\u2010on\u2010metal total joint arthroplasties: a role of metallic byproducts?","volume":"164","author":"Hobza M","year":"2020","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-3019-y"},{"key":"e_1_2_10_31_1","volume-title":"Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part A","author":"Nakamoto K","year":"2009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34408"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotri.2021.100163"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.715"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-005-0066-7"},{"key":"e_1_2_10_36_1","first-page":"17","article-title":"\"modes of failure\" of cemented stem\u2010type femoral components: a radiographic analysis of loosening","volume":"141","author":"Gruen TA","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32700"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.9b00745"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.08.051"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213902"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.08.018"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B1.36374"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000412"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2020.1702024"},{"issue":"1","key":"e_1_2_10_45_1","first-page":"1","article-title":"A Tribological and ion released research of Ti\u2010materials for medical devices","volume":"15","author":"Silva D","year":"2022","journal-title":"Materials"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.35149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:16:49Z","timestamp":1692577009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jbm.b.35149"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35149","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]},"assertion":[{"value":"2021-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}