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The current study aims to investigate the therapeutic efficacy of cell\u2010penetrating peptide\u2010based targeted delivery of vancomycin functionalized quantum dots in eradicating biofilm formation in gram\u2010positive and gram\u2010negative bacterial strains. The conjugate was characterized using fluorimetry, UV\u2013visible spectroscopy, gel electrophoresis, and zeta potential. The conjugate was then tested for antimicrobial and antibiofilm activity against <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Escherichia coli<\/jats:italic>, and it demonstrated excellent antimicrobial as well as antibiofilm activity against all the tested strains. 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