{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:53:27Z","timestamp":1791021207723,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydroxyapatite (\n                    <jats:italic>HA<\/jats:italic>\n                    ) powders were synthesized by the wet precipitation method in which two experimental compositions were synthesized (10\u00a0mol%\n                    <jats:italic>Ag\u2010HA<\/jats:italic>\n                    and\n                    <jats:italic>Cu\u2010HA<\/jats:italic>\n                    ) where the CaNO\n                    <jats:sub>3<\/jats:sub>\n                    content was partially substituted with AgNO\n                    <jats:sub>3<\/jats:sub>\n                    and Cu(NO\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    . X\u2010ray diffraction (XRD) was employed to characterize changes to the\n                    <jats:italic>HA<\/jats:italic>\n                    structure as the dopants (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , Ag\n                    <jats:sup>+<\/jats:sup>\n                    ) were incorporated into the materials structure. Energy\u2010dispersive X\u2010ray spectroscopy (EDS) determined confirmed the compositions and found that the Ca\/P ratio was 1.63 for the control (\n                    <jats:italic>HA<\/jats:italic>\n                    ) while\n                    <jats:italic>Ag\u2010HA<\/jats:italic>\n                    and\n                    <jats:italic>Cu\u2010HA<\/jats:italic>\n                    exhibited (X\u2009+\u2009Ca)\/P ratios of 1.79 and 1.65, respectively. Antibacterial efficacies were evaluated against\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    and\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    , as a function of surface area and incubation time. The more prominent antibacterial effects were observed with both\n                    <jats:italic>Ag\u2010HA<\/jats:italic>\n                    and\n                    <jats:italic>Cu\u2010HA<\/jats:italic>\n                    and the materials antibacterial influence was maintained with respect to time. Ion release studies of each\n                    <jats:italic>HA<\/jats:italic>\n                    composition (15, 30, and 45\u2009days) showed that\n                    <jats:italic>Cu\u2010HA<\/jats:italic>\n                    released significantly more Cu\n                    <jats:sup>2+<\/jats:sup>\n                    (36.1\u2009\u00b1\u20095.1\u00a0mg\/L) than Ag\n                    <jats:sup>+<\/jats:sup>\n                    (2.9\u2009\u00b1\u20091.2\u00a0mg\/L) from\n                    <jats:italic>Ag\u2010HA<\/jats:italic>\n                    . Analysis of each composition incubated in simulated body fluid (SBF) exhibited surface depositions that are likely calcium phosphate (CaP). Cytocompatibility testing in MC 3T3 Osteoblasts showed slight reductions in cell viability when tested using MTT assay, however cell adhesion studies were positive for each composition.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35151","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T05:49:01Z","timestamp":1662097741000},"page":"295-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Investigating the structure, solubility, and antibacterial properties of silver\u2010 and copper\u2010doped hydroxyapatite"],"prefix":"10.1002","volume":"111","author":[{"given":"Katie M.","family":"Weiss","sequence":"first","affiliation":[{"name":"Inamori School of Engineering Alfred University Alfred New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra K.","family":"Kucko","sequence":"additional","affiliation":[{"name":"Inamori School of Engineering 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