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The previous study in vitro has shown that the amino\u2010functionalized carbon fiber reinforced PEEK (A\u201030%\u2010CPEEK) possessed enhanced mechanical property and bioactivity. This study aims to evaluate the effect of amino groups modification on the osseointegration behavior of carbon fiber reinforced PEEK (30%\u2010CPEEK) in rabbits. Herein, 30%\u2010CPEEK and A\u201030%\u2010CPEEK implant discs were implanted in rabbit skulls for 5\u2009weeks, with pure titanium implants serving as a control. The bone\u2010forming ability and osseointegration in vivo were systematically investigated by micro\u2010computed tomography analysis, scanning electron microscope observation, and histological evaluation. Our results showed that all detection parameters were significantly different between the A\u201030%\u2010CPEEK and 30%\u2010CPEEK groups, favoring those in the A\u201030%\u2010CPEEK, whose appraisal parameters were equal to or better than pure titanium. Therefore, this study supported the importance of amino groups in facilitating the new bone formation and bone\u2010implant integration, suggesting that A\u201030%\u2010CPEEK with enhanced osseointegration will be a promising material for dental or orthopedic implants.<\/jats:p>","DOI":"10.1002\/jbm.b.35167","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T19:29:53Z","timestamp":1664825393000},"page":"505-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Osseointegration behavior of carbon fiber reinforced polyetheretherketone composites modified with amino groups: An in vivo study"],"prefix":"10.1002","volume":"111","author":[{"given":"Junyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dental Implantology, Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone 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