{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:58Z","timestamp":1790741998123,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Periodontitis is a chronic inflammatory disease that leads to the loss of alveolar bone, among several studies focusing on reconstructing periodontal bone caused by periodontitis, guided bone regeneration (GBR) is a promising approach. In this study a serial clinically applied antibiotics loaded poly(L\u2010lactide\u2010co\u2010glycolide)\/poly(L\u2010lactide\u2010co\u2010\u03b5\u2010caprolactone) (PLGA\/PLCA) fibrous mesh to prevent and reconstruct defective bone in periodontitis were prepared by electrospinning. Incorporation of antibiotics promoted the hydrophilicity but decreased the crystallinity of PLGA\/PLCA membranes. Antibiotics could be sustained released from membranes. Metronidazole, minocycline, and doxycycline incorporated membranes could suppress\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    ) within 21\u2009days in vitro. Metronidazole and minocycline incorporated membranes decreased 41% and 55.5% colony counts in rat gingival crevicular fluid in vivo. Minocycline\u2010loaded membrane could support the proliferation of MC3T3\u2010E1 cells and maintained 79% viability of human ligament fibroblasts cultured on it. And MC3T3\u2010E1 cells could undergo osteoblastic differentiation when cultured with pure PLGA\/PLCA membrane and minocycline incorporated membrane. Then in vivo repairable effects of those antibiotics loaded membranes were evaluated in alveolar bone defected\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    infected model. The application of minocycline loaded membranes, effectively prevented the bone resorption of periodontitis caused by\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . After been treated with minocycline incorporated membrane, volume of defected bone of maintained at about 50% level of control rats. 8\u2009weeks post\u2010operation, newly regenerated bone was observed in the operative alveolar bone of the pure PLGA\/PLCA membrane, metronidazole and minocycline incorporated PLGA\/PLCA membrane treated groups. Minocycline\/PLGA\/PLCA electrospinning membrane is a promising GBR material that can be applied to guide regeneration of periodontitis\u2010induced alveolar bone damage.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35168","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T06:59:22Z","timestamp":1664953162000},"page":"513-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comprehensive reparative effects of bacteriostatic poly(L\u2010lactide\u2010co\u2010glycolide)\/poly(L\u2010lactide\u2010co\u2010\u03b5\u2010caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis"],"prefix":"10.1002","volume":"111","author":[{"given":"Yiming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology North Sichuan Medical College &amp; Affiliated Hospital of North Sichuan Medical College  Nanchong 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Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-8584","authenticated-orcid":false,"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Pharmacy, North Sichuan Medical College  Nanchong 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