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Mechanical, structural, and transport properties of vascular grafts are critical factors that substantially affect their function and thus the outcome of implantation. The manufacturing method, post\u2010processing technique, and material of choice have a significant impact on these properties. The goal of this work is to use thermal treatment to modulate the transport properties of PCL\u2010based vascular engineered constructs. To this end, we electrospun PCL tubular constructs and thermally bonded the electrospun fibers in a convective oven at various temperatures (54, 57, and 60\u00b0C) and durations of treatment (15, 30, and 45\u2009s). The effects of fiber thermal bonding (thermobonding) on the transport, mechanical, and structural properties of PCL tubular constructs were characterized. Increasing the temperature and treatment duration enhanced the degree of thermobonding by removing the interconnected void and fusing the fibers. Thermobonding at 57\u00b0C and 60\u00b0C for longer than 30\u2009s increased the median tangential modulus (<jats:italic>E<\/jats:italic>\u00a0=\u00a0126.1\u2009MPa, [IQR\u00a0=\u00a020.7]), mean suture retention (<jats:italic>F<\/jats:italic>\u00a0=\u00a0193.8\u2009g, [SD\u00a0=\u00a018.5]), and degradation rate while it decreased the median permeability (<jats:italic>k<\/jats:italic><jats:sub>A<\/jats:sub>\u00a0=\u00a00\u2009m\/s), and median thickness (<jats:italic>t<\/jats:italic>\u00a0=\u00a060\u2009\u03bcm, [IQR\u00a0=\u00a02.5]). In particular, the thermobonding at 57\u00b0C allowed a finer modulation of permeability via treatment duration. We believe that the thermobonding method can be utilized to modulate the properties of vascular engineered constructs which can be useful in designing functional vascular grafts.<\/jats:p>","DOI":"10.1002\/jbm.b.35181","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:51:31Z","timestamp":1665553891000},"page":"622-632","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanical alterations of electrospun poly(<i>\u03f5<\/i>\u2010caprolactone) in response to convective thermobonding"],"prefix":"10.1002","volume":"111","author":[{"given":"Ali","family":"Behrangzade","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah R.","family":"Keeney","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina M.","family":"Martinet","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Chemical Engineering University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"McGowan Institute for Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Vande Geest","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"McGowan Institute for Regenerative Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Mechanical Engineering and Material Science University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1528083716654470"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-003-0232-x"},{"key":"e_1_2_9_4_1","first-page":"9","article-title":"Compliance mismatch may promote graft\u2014artery intimal hyperplasia by altering suture\u2010line stresses","volume":"31","author":"Ballyk P","year":"1998","journal-title":"J Biomech"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00099"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802651477"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.06.035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2005.11.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.11.024"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33201"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.13005\/bbra\/2676"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-055294-1.00218-X"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.64098-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53349-4.00270-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3144\/expresspolymlett.2015.6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12030693"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.10.002"},{"key":"e_1_2_9_19_1","unstructured":"EzeakachaCP RabbaniA SalehiS GhalamborA.Integrated image processing and computational techniques to characterize formation damage. 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