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To explore the development feasibility of cross\u2010linked PGA as a novel dermal filler, we studied the local skin response to PGA fillers and the effect of various cross\u2010linking preparations on the average longevity of dermal injection. Injection site inflammation and the formation of collagen and elastin were also determined. PGA hydrogel particles prepared using 28% PGA and 10% 1,4\u2010butanediol diglycidyl ether showed optimal filler properties, resistance to moist heat sterilization, and an average filling longevity of 94.7\u2009\u00b1\u200961.6\u2009days in the dermis of rabbit ears. Local redness and swelling due to filler injection recovered within 14.2\u2009\u00b1\u20093.6\u2009days. Local tissue necrosis or systemic allergic reactions were not observed, and local collagen formation was promoted. Preliminary results suggested that dermal injection of cross\u2010linked PGA particles appeared safe and effective, suggesting that cross\u2010linked PGA particles could be developed as a new hydrogel dermal filler.<\/jats:p>","DOI":"10.1002\/jbm.b.35245","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T15:09:42Z","timestamp":1679065782000},"page":"1407-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparation, function, and safety evaluation of a novel degradable dermal filler, the cross\u2010linked poly\u2010\u03b3\u2010glutamic acid hydrogel particles"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-8957","authenticated-orcid":false,"given":"Mian","family":"Chen","sequence":"first","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of 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