{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:45:02Z","timestamp":1780371902349,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the bone healing of tight\u2010fit implants placed in the maxilla and mandible of subjects compromised with metabolic syndrome (MS) and type\u20102 Diabetes Mellitus (T2DM). Eighteen G\u00f6ttingen minipigs were randomly distributed into three groups: (i) control (normal diet), (ii) MS (cafeteria diet for obesity induction), (iii) T2DM (cafeteria diet for obesity induction\u2009+\u2009Streptozotocin for T2DM induction). Maxillary and mandibular premolars and molar were extracted. After 8 weeks of healing, implants with progressive small buttress threads were placed, and allowed to integrate for 6\u2009weeks after which the implant\/bone blocks\u00a0were retrieved for histological processing. Qualitative and quantitative histomorphometric analyses (percentage of bone\u2010to\u2010implant contact, %BIC, and bone area fraction occupancy within implant threads, %BAFO) were performed. The bone healing process around the implant occurred predominantly through interfacial remodeling with subsequent bone apposition. Data as a function of systemic condition yielded significantly higher %BIC and %BAFO values for healthy and MS relative to T2DM. Data as a function of maxilla and mandible did not yield significant differences for either %BIC and %BAFO. When considering both factors, healthy and MS subjects had %BIC and %BAFO trend towards higher values in the mandible relative to maxilla, whereas T2DM yielded higher %BIC and %BAFO in the maxilla relative to mandible. All systemic conditions presented comparable levels of %BIC and %BAFO in the maxilla; healthy and MS presented significantly higher %BIC and %BAFO relative to T2DM in the mandible. T2DM presented lower amounts of bone formation around implants relative to MS and healthy. Implants placed in the maxilla and in the mandible showed comparable amounts of bone in proximity to implants.<\/jats:p>","DOI":"10.1002\/jbm.b.35264","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T13:32:34Z","timestamp":1684157554000},"page":"1664-1671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bone healing around implants placed in subjects with metabolically compromised systemic conditions"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-2184","authenticated-orcid":false,"given":"Edmara T. P.","family":"Bergamo","sequence":"first","affiliation":[{"name":"Biomaterials Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Prosthodontics University of Sao Paulo, School of Dentistry  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"additional","affiliation":[{"name":"Biomaterials Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Biomedical Engineering NYU Tandon School of Engineering  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics University of Sao Paulo, School of Dentistry  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo C. O.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics University of Sao Paulo, School of Dentistry  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-0339","authenticated-orcid":false,"given":"Vasudev Vivekanand","family":"Nayak","sequence":"additional","affiliation":[{"name":"Biomaterials Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Mechanical and Aerospace Engineering Tandon School of Engineering  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-8350","authenticated-orcid":false,"given":"Estevam A.","family":"Bonfante","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics University of Sao Paulo, School of Dentistry  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Tovar","sequence":"additional","affiliation":[{"name":"Biomaterials Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Oral and Maxillofacial Surgery NYU Langone Medical Center and Bellevue, Hospital Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Torroni","sequence":"additional","affiliation":[{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery Grossman School of Medicine, New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"DeWitt Daughtry Family Department of Surgery, Division of Plastic Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.81.2.341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00899-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.06.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.09.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068177"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002727-200404000-00003"},{"key":"e_1_2_8_9_1","unstructured":"GuytonACH J.E.Textbook of medical physiology.2006."},{"issue":"4","key":"e_1_2_8_10_1","first-page":"12","article-title":"The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus","volume":"4","author":"Ozougwu JCO","year":"2013","journal-title":"J Phys Pathophysiol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0284-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802126"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04292.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.2.0461"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4854"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.11.1271"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509334203"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01746.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.02.021"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00536"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.05.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050514"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V82260"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2020.103436"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12288"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.033"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2014.10.007"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.07.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5340"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33463"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073087"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.03.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100520"},{"key":"e_1_2_8_34_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10\u2010year period","volume":"16","author":"Branemark PI","year":"1977","journal-title":"Scand J Plast Reconstr Surg Suppl"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-199807040-00004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008505-200009020-00006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ID.0000086482.65273.B7"},{"issue":"5","key":"e_1_2_8_38_1","first-page":"620","article-title":"Wound healing around endosseous implants in experimental diabetes","volume":"13","author":"Nevins ML","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000836"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039526.42991.93"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-1070-9"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.7.775"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1595-0"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0229-0"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0922(09)73516-8"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00972.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512463240"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33020"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2011.06.016"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00153.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2014.03.017"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8132520"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.2020034194"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb9010007"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13007"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2008.00084.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001067"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0226"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0658"},{"issue":"2","key":"e_1_2_8_60_1","first-page":"150","article-title":"The obese Gottingen minipig as a model of the metabolic syndrome: dietary effects on obesity, insulin sensitivity, and growth hormone profile","volume":"51","author":"Johansen T","year":"2001","journal-title":"Comp Med"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:02:04Z","timestamp":1692309724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/jbm.b.35264"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35264","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"2022-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}