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Silymarin (SM) is a natural compound extracted from plants, and has been shown to have pharmacological effects such as antioxidant, anti\u2010inflammatory, cytoprotective, and anti\u2010nephrotoxicity. SM\u2010modified polysulfone (PSF) hemodialysis membranes were prepared by an immersion\u2010precipitation phase transition method. The experimental results showed that the modified membranes effectively scavenged free radicals, significantly inhibited lipid peroxidation, and had good antioxidant stability (60\u2009days). The PSF\/SM antioxidant membranes (H\u20103) had no pro\u2010inflammatory effect, which was confirmed by the result of anti\u2010M1 macrophage polarization. Furthermore, the hemolysis rate (2%), blood cell deformation (3.7%), and inhibition of erythrocyte and platelet adhesion were improved by the SM\u2010modified PSF membranes. All the results suggest that PSF\/SM blended hollow fiber membranes are promising for application in hemodialysis membranes to improve oxidative stress status and reduce inflammation and complications in patients.<\/jats:p>","DOI":"10.1002\/jbm.b.35285","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:09:41Z","timestamp":1685531381000},"page":"1785-1799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Silymarin modified polysulfone hollow fiber membranes with antioxidant, <scp>anti\u2010M1<\/scp> macrophage polarization and hemocompatibility for blood purification"],"prefix":"10.1002","volume":"111","author":[{"given":"Peichen","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Separation Membranes and Membrane Processes, National Center for International Joint Research on Separation Membranes, School of Materials Science and Engineering 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