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One of several factors that could be associated with mesh\u2010related POP complications is changes in the properties of the implanted surgical mesh due to oxidative degradation of PP in vivo. Currently, there are no standardized in vitro bench testing methods available for assessing the susceptibility to oxidative degradation and estimating long\u2010term in vivo stability of surgical mesh. In this work, we adapted a previously reported automated reactive accelerated aging (aRAA) system, which uses elevated temperatures and high concentrations of hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), for accelerated bench\u2010top oxidative degradation testing of PP surgical mesh. Since H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> is highly unstable at elevated temperatures and for prolonged periods, the aRAA system involves a feedback loop based on electrochemical detection methods to maintain consistent H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> concentration in test solutions. Four PP mesh samples with varying mesh knit designs, filament diameter, weight, and % porosity, were selected for testing using aRAA up to 4\u2009weeks and characterized using thermal analysis, Fourier\u2010transform infrared spectroscopy\u2010attenuated total reflectance (FTIR\u2010ATR) and scanning electron microscopy (SEM). Additionally, the oxidation index (OI) values were calculated based on the FTIR\u2010ATR spectra to estimate the oxidative degradation and oxidation reaction kinetics of PP surgical mesh. The OI values and surface damage in the form of surface flaking, peeling, and formation of transverse cracks increased with aRAA aging time. The aRAA test method introduced here could be used to standardize the assessment of long\u2010term stability of surgical mesh and may also be adopted for accelerated oxidative degradation testing of other polymer\u2010based medical devices.<\/jats:p>","DOI":"10.1002\/jbm.b.35308","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T22:03:53Z","timestamp":1692655433000},"page":"2064-2076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Accelerated in vitro oxidative degradation testing of polypropylene surgical mesh"],"prefix":"10.1002","volume":"111","author":[{"given":"Tanmay","family":"Jain","sequence":"first","affiliation":[{"name":"Division of Biology, Chemistry and Materials Science U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinnapatch","family":"Tantisuwanno","sequence":"additional","affiliation":[{"name":"Department of Polymer Science The University of Akron  Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arindam","family":"Paul","sequence":"additional","affiliation":[{"name":"Division of Biology, Chemistry and Materials Science U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Takmakov","sequence":"additional","affiliation":[{"name":"Division of Biology, Chemistry and Materials Science U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Joy","sequence":"additional","affiliation":[{"name":"Department of Polymer Science The University of Akron  Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irada","family":"Isayeva","sequence":"additional","affiliation":[{"name":"Division of Biology, Chemistry and Materials Science U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-6745","authenticated-orcid":false,"given":"David D.","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Biology, Chemistry and Materials Science U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories  Silver Spring Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004857"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2016.05.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/968087"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1267521"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/jovs.2017.06.10"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010019\u201008168\u2010z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2016.17.3.135"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.11.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010018\u20101776\u20102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011517.pub2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd006438.pub2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.07.029"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006375.pub4"},{"key":"e_1_2_9_15_1","unstructured":"EpsteinM EmriI HartemannP et al.Scientific committee on emerging and newly Identified health Risks (SCENIHR).Opinion on the Safety of Surgical Meshes Used in Urogynecological Surgery.201510.2772\/63702"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31596\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585\u2010019\u20100230\u20102"},{"key":"e_1_2_9_18_1","unstructured":"US Food and Drug Administration. 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