{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:09:33Z","timestamp":1777072173855,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effectiveness and safety of a new composite\u2010based biodegradable anterior cervical plate\/screw (ACPS) system for the anterior cervical discectomy and fusion (ACDF) fixation. A biocomposite in combination with 30\u2009wt% \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP; a biodegradable ceramic having osteoconductive ability) and 70\u2009wt% poly\u2010<jats:sc>l<\/jats:sc>\/<jats:sc>d<\/jats:sc>\u2010lactide copolymer (PLDLA; a biodegradable polymer) was developed and used in the ACPS device, comprising one plate and four screws for fixation. Based on a literature review, a clinically required period of performance maintenance was set as 16\u2009weeks, and to verify the performance for a period of 16\u2009weeks or more, the test was conducted for 26\u2009weeks. Following ISO 13781:2017 testing protocols, an in vitro degradation test was performed to verify the performance and evaluate the decomposition characteristics of the biodegradable ACPS system. Using an animal model as a preclinical investigation, the prepared ACPS device was implanted into five mongrel dogs weighing over 30\u2009kg to evaluate the detachment prevention effect of the ACPS system on polyether ether ketone (PEEK) cage after ACDF. By week 26, the molecular weight was decreased by 45.35% for the plate and 52.56% for the screw; the bending strength of the plate was decreased by approximately 26.2% when compared with the initial stage. The torsional yield strength and pullout strength of the screw was increased by 52.31% and 5.3%, respectively by week 2 and then subsequently decreased until week 26. No detachment or dislocation of the inserted PEEK cage was observed for 26\u2009weeks in vivo study. These findings recommend that the ACPS system might be a promising biodegradable tool for the fixation of interbody implants and supporting the fusion in an ACDF model. Furthermore, additional clinical trials are planned for the future.<\/jats:p>","DOI":"10.1002\/jbm.b.35323","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:40:19Z","timestamp":1693896019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a novel <scp>PLDLA<\/scp>\/<scp>\u03b2\u2010TCP<\/scp> composite\u2010based biodegradable anterior cervical plate and screw system"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-1460","authenticated-orcid":false,"given":"Younghoon","family":"Kwon","sequence":"first","affiliation":[{"name":"OSTEONIC Co., Ltd.  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-4233","authenticated-orcid":false,"given":"Mosharraf","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Medicine Soonchunhyang University, Bucheon Hospital  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-6503","authenticated-orcid":false,"given":"Minsu","family":"Lee","sequence":"additional","affiliation":[{"name":"OSTEONIC Co., Ltd.  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-0113","authenticated-orcid":false,"given":"Je Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Medicine Soonchunhyang University, Bucheon Hospital  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.1.3289089"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1752-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70014-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"PatilPG TurnerDA PietrobonRJN.National Trends in surgical procedures for degenerative cervical spine disease.Neurosurgery. 1990\u20132000.2005;57(4):753\u2010758.","DOI":"10.1227\/01.NEU.0000175729.79119.1d"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.6.SPINE08838"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-172"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910269"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.85.2.0206"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499019869166"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2006.04.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002441"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4184\/jkss.2005.12.1.22"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181b64f2c"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200001010-00009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"JeonT\u2010S ChangH ChoiBWJ.Current concept on the operative treatment for degenerative cervical disc disease.J Korean Med Assoc.2011;54(9):941\u2010950.","DOI":"10.5124\/jkma.2011.54.9.941"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.11.008"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"440","article-title":"Feasibility of a resorbable anterior cervical graft containment plate","volume":"97","author":"Ames CP","year":"2002","journal-title":"J Neurosurg"},{"issue":"4","key":"e_1_2_10_19_1","first-page":"169","article-title":"Use of resorbable implants for symptomatic cervical spondylosis: experience on 16 consecutive patients","volume":"51","author":"Franco A","year":"2007","journal-title":"J Neurosurg Sci"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.04.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000175185.46433.7a"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-023-00338-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00190-X"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.09.031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S38127"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190050"},{"key":"e_1_2_10_27_1","unstructured":"RobinsonR.Anterolateral disc removal and interbody fusion for cervical disc syndrome.Bull Johns Hopkins Hosp.\u00a01955;96:223\u2010224."},{"key":"e_1_2_10_28_1","unstructured":"OrozcoRJROT.Osteos\u00edntesis en las fracturas del raquis cervical.Rev Ortop Traumatol.1970;14:285\u2010288."},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","unstructured":"ParkHJ RahJH YoonYS.Anterior cervical fusion with cervical spine locking plate system.J Korean Orthop Assoc.1996;31(1):52\u201058.","DOI":"10.4055\/jkoa.1996.31.1.52"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/501789"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856299X00234"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.3.2.79"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30091"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30238"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2016.05.003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","unstructured":"Sun MajiWQ XingchenZ ChongG FengY KaijinG.Development and biomechanical analysis of a new anterior cervical pedicle screw fixation system.Chin J Tis Eng Res.2021;25(24):3821\u20103825.","DOI":"10.21203\/rs.3.rs-150237\/v1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19970905)36:3<360::AID-JBM11>3.0.CO;2-I"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31531"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","unstructured":"KimD\u2010H JeongS\u2010T AnS\u2010H ParkH\u2010B HwangS\u2010C ChoS\u2010H.Effectiveness of the new modified smith\u2010robinson bone graft for cervical anterior interbody fusion.J Korean Orthop Assoc.\u00a02008;43(1):101\u2010106.","DOI":"10.4055\/jkoa.2008.43.1.101"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","unstructured":"WeilerA HoffmannRF St\u00e4helinAC HellingH\u2010J S\u00fcdkampN.Biodegradable implants in sports medicine: the biological base.Arthroscopy.2000;16(3):305\u2010321.","DOI":"10.1016\/S0749-8063(00)90055-0"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:49:06Z","timestamp":1754484546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jbm.b.35323"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35323","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,5]]},"assertion":[{"value":"2023-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35323"}}