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In this study, we coated porous bioactive glass 13\u201393 scaffolds with amorphous, homocrystalline, or stereocomplex PLA to investigate their mechanical and degradation properties before and after immersion in simulated body fluid. The glass scaffolds had interconnected pores and an average porosity of 76%. The PLA coatings, which were 10\u2013100\u2009\u03bcm thick and approximately 3% of the glass scaffold mass, covered the glass to a large extent. The compressive strength and toughness of all PLA\u2010coated scaffolds were significantly higher than those of uncoated scaffolds, with approximately a fourfold increase before immersion and a twofold increase after immersion. The compressive strength and toughness of PLA SC\u2010coated scaffolds were similar to those of scaffolds with homocrystalline PLA coating, and significantly higher than for scaffolds with amorphous PLA coating. All PLA coatings moderated the initial pH increase caused by the glass, which could benefit surrounding cells and bone tissue in vivo after implantation.<\/jats:p>","DOI":"10.1002\/jbm.b.35328","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:13:39Z","timestamp":1695363219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of polylactide coating stereochemistry on mechanical and in vitro degradation properties of porous bioactive glass scaffolds for bone regeneration"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-3355","authenticated-orcid":false,"given":"Peter","family":"Uppstu","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Science and Technology, Faculty of Science and Engineering \u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-5186","authenticated-orcid":false,"given":"Simon","family":"Engblom","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Science and Technology, Faculty of Science and Engineering \u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Inkinen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Science and Technology, Faculty of Science and Engineering \u00c5bo Akademi University  Turku Finland"},{"name":"Nordic Catalyst e.U.  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