{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:40:25Z","timestamp":1771339225546,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to (1) comparatively analyze properties of Sr\u2010 and Mg\u2010substituted hydroxyapatite (HAP)\u2010based dental inserts; (2) evaluate insert bonding to restorative materials, and (3) evaluate the effect of doped HAP inserts on fracture resistance (FR) of human molars with large occlusal restorations. By ion\u2010doping with Sr or Mg, 3 insert types were obtained and characterized using XRD, SEM, Vickers hardness and fracture toughness. Shear bond strength (SBS) was determined between acid etched or unetched inserts and following materials: Maxcem cement (Kerr); Filtek Z250 (3M) bonded with Single Bond Universal (SBU; 3M) or Clearfil Universal (Cf; Kuraray). Modified Class I cavities were prepared in 16 intact molars and restored using insert\u2009+\u2009composite or composite only (control) (<jats:italic>n<\/jats:italic>\u2009=\u20098\/group). FR of restored molars was determined by static load until fracture upon thermal cycling. Fracture toughness was similar between Sr\/Mg\u2010doped inserts (0.94\u20131.04 MPam<jats:sup>\u22121\/2<\/jats:sup> <jats:italic>p<\/jats:italic>\u2009=\u2009.429). Mg\u2010doped inserts showed greater hardness (range 4.78\u20135.15\u2009GPa) than Sr6 inserts (3.74\u2009\u00b1\u20090.31\u2009GPa; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). SBS for SBU and Cf adhesives (range 7.19\u201315.93\u2009MPa) was higher than for Maxcem (range 3.07\u20135.95\u2009MPa) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). There was no significant difference in FR between molars restored with insert\u2010containing and control restorations (3.00\u2009\u00b1\u20090.30\u2009kN and 3.22\u2009\u00b1\u20090.42\u2009kN, respectively; <jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). HAP\u2010based inserts doped with Mg\/Sr had different composition and mechanical properties. Adhesive bonding to inserts resulted in greater bond strength than cementation, which may be improved by insert acid\u2010etching. Ion\u2010doped HAP inserts did not affect FR of restored molars. In conclusion, HAP\u2010based dental inserts may potentially replace dentin in large cavities, without affecting fracture resistance of restored teeth.<\/jats:p>","DOI":"10.1002\/jbm.b.35331","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:20:26Z","timestamp":1696418426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hydroxyapatite\u2010based dental inserts: Microstructure, mechanical properties, bonding efficiency and fracture resistance of molars with occlusal restorations"],"prefix":"10.1002","volume":"112","author":[{"given":"Tamara","family":"Matic","sequence":"first","affiliation":[{"name":"Innovation Center of the Faculty of Technology and Metallurgy, Ltd  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja Lezaja","family":"Zebic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Miletic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Dental School The University of Sydney  Surry Hills New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaak","family":"Trajkovic","sequence":"additional","affiliation":[{"name":"Innovation Center of the Faculty of Mechanical Engineering, Ltd  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Innovation Center of the Faculty of Mechanical Engineering, Ltd  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Racic","sequence":"additional","affiliation":[{"name":"School of Dental Medicine University of Belgrade  Belgrade 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