{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:56:13Z","timestamp":1788328573870,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of novel implants subjected to surface modification to achieve high osteointegration properties at simultaneous antimicrobial activity is a highly current problem. This study involved different surface treatments of titanium surface, mainly by electrochemical oxidation to produce a nanotubular oxide layer (TNTs), a subsequent electrochemical reduction of silver nitrate and decoration of a nanotubular surface with silver nanoparticles (AgNPs), and finally electrophoretic deposition (EPD) of a composite of chitosan (CS) and either polymethacrylate\u2010based copolymer Eudragit E 100 (EE100) or poly(4\u2010vinylpyridine) (P4VP) coating. The effects of each stage of this multi\u2010step modification were examined in terms of morphology, roughness, wettability, corrosion resistance, coating\u2010substrate adhesion, antibacterial properties, and osteoblast cell adhesion and proliferation. The results showed that the titanium surface formed nanotubes (inner diameter of 97\u2009\u00b1\u200912\u2009nm, length of 342\u2009\u00b1\u200936\u2009nm) subsequently covered with silver nanoparticles (with a diameter of 88\u2009\u00b1\u20098\u2009nm). Further, the silver\u2010decorated nanotubes were tightly coated with biopolymer films. Most of the applied modifications increased both the roughness and the surface contact angle of the samples. The deposition of biopolymer coatings resulted in reduced burst release of silver. The coated samples revealed potent antimicrobial activity against both Gram\u2010positive and Gram\u2010negative bacteria. Total elimination (99.9%) of\n                    <jats:italic>E. coli<\/jats:italic>\n                    was recorded for a sample with CS\/P4VP coating. Cytotoxicity results using hFOB 1.19, a human osteoblast cell line, showed that after 3\u2009days the tested modifications did not affect the cellular growth according to the titanium control. The proposed innovative multilayer antibacterial coatings can be successful for titanium implants as effective postoperative anti\u2010inflammation protection.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35332","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T06:21:06Z","timestamp":1695190866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cytocompatibility, antibacterial, and corrosion properties of chitosan\/polymethacrylates and chitosan\/poly(4\u2010vinylpyridine) smart coatings, electrophoretically deposited on nanosilver\u2010decorated titania nanotubes"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-9207","authenticated-orcid":false,"given":"\u0141ukasz","family":"Paw\u0142owski","sequence":"first","affiliation":[{"name":"Institute of Manufacturing and Materials Technology, Faculty of Mechanical Engineering and 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