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In this study, a biohybrid scaffold of the decellularized caprine pericardium (DCP) and graphene oxide (GO) was fabricated by an immersion coating technique. The antimicrobial activity of GO was evaluated against <jats:italic>Escherichia coli<\/jats:italic> and showed minimum inhibitory concentration at 125\u2009\u03bcg\/mL and minimum bactericidal concentration at 250\u2009\u03bcg\/mL. The presence of GO on the surface of the biohybrid GO\u2010DCP was confirmed through SEM analysis. The existence of glycosaminoglycan, elastin, and collagen in the DCP and GO\u2010DCP was inferred from the FTIR spectra. The biocompatibility of GO\u2010DCP was studied by seeding valvular interstitial cells, and the results show GO coating supports cell adhesion on the serous and fibrous sides of the DCP. Further, the biomechanical response of DCP is unaltered by the presence of GO. In conclusion, GO enhances the biological performance of decellularized pericardium, which can be used in cardiac tissue engineering applications.<\/jats:p>","DOI":"10.1002\/jbm.b.35353","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:29:11Z","timestamp":1700094551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of physicochemical properties of graphene oxide\u2010decellularized pericardium biohybrid scaffold"],"prefix":"10.1002","volume":"112","author":[{"given":"Thirumalai","family":"Deepak","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Medical Engineering National Institute of Technology Rourkela  Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bansod Sneha","family":"Bharat","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Medical Engineering National Institute of Technology Rourkela  Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"R. 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