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Aldehyde crosslinker\u2010containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the aortic media; however, they show low biocompatibility due to the release of aldehyde compounds. In this study, we report innovative adhesives based on hydrophobically modified Alaska pollock gelatin (hm\u2010ApGltn) with different alkyl or cholesteryl (Chol) groups that adhere to the media of the dissected aorta by combining hm\u2010ApGltns with a biocompatible crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate. The modification of alkyl or Chol groups contributed to enhanced adhesion strength between porcine aortic media. The adhesion strength increased with increasing modification ratios of alkyl groups from propanoyl to dodecanoyl groups and then decreased at a modification ratio of ~20\u2009mol %. Porcine aortic media adhered using 7.5Chol\u2010ApGltn adhesive showed stretchability even when expanded and shrunk vertically by 25% at least five times. Hm\u2010ApGltn adhesives subcutaneously injected into the backs of mice showed no severe inflammation and were degraded during the implantation period. These results indicated that hm\u2010ApGltn adhesives have potential applications in type\u2010A aortic dissection.<\/jats:p>","DOI":"10.1002\/jbm.b.35361","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T03:33:51Z","timestamp":1704425631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin\u2010based adhesive for aortic dissections"],"prefix":"10.1002","volume":"112","author":[{"given":"Temmei","family":"Ito","sequence":"first","affiliation":[{"name":"Graduate School of Pure and Applied Sciences University of Tsukuba  Tsukuba Japan"},{"name":"Biomaterials Field, Research Center for Macromolecules and Biomaterials, National Institute for Materials Science  Tsukuba 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