{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:50:53Z","timestamp":1785441053670,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018504","name":"Nipro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerve injuries (PNIs) include complete and partial transection, crushing, and chronic compression injuries. Hollow absorbable conduits are used to treat complete transection with short defects, while wrapping the injured part with an absorbent material promotes nerve recovery by inhibiting inflammatory cell infiltration and scar tissue formation in crush injuries. For treatment of partially transected nerve injuries (PTNIs), such as injection\u2010related iatrogenic PNI, whether wrapping the entire nerve, including the injury site, or bridging the transected fascicle with an artificial nerve conduit (ANC) is beneficial remains to be verified. The purpose of this study was to investigate whether wrapping the injured nerve and placing collagen fibers as scaffolds at the nerve defect site contribute to neural recovery in PTNI. A unilateral 5\u2010mm partial nerve defect was created at the mid\u2010thigh level in a rat sciatic nerve injury model. Fifty\u2010four Sprague\u2013Dawley (SD) rats (150\u2013250\u2009g) were divided into three groups (<jats:italic>n<\/jats:italic>\u2009=\u20099 each): group 1, collagen fibers were placed in the nerve defect and the sciatic nerve was wrapped with collagen conduit; group 2, the sciatic nerve was wrapped by collagen conduit without collagen fibers; and group 3, nerve defect was reconstructed with collagen\u2010filled conduit. Nerve regeneration was evaluated by analyses of gait, electrophysiology, wet muscle weight, and axon numbers with immunohistochemistry at 12 and 24\u2009weeks. Dorsiflexion angles among all groups improved significantly from 12 to 24\u2009weeks postoperatively. At 24\u2009weeks postoperatively, compound muscle action potential amplitudes (CMAPs) of tibialis anterior were 5.26\u2009\u00b1\u20094.64, 1.31\u2009\u00b1\u20091.17, and 0.14\u2009\u00b1\u20090.24\u2009mV (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), CMAPs of gastrocnemius were 21.3\u2009\u00b1\u20095.98, 15.4\u2009\u00b1\u20095.46, and 13.11\u2009\u00b1\u20093.91\u2009mV in groups 1, 2, and 3, respectively; and the value of group 1 was significantly higher than that of group 3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Axon numbers were 2194\u2009\u00b1\u2009629; 1106\u2009\u00b1\u2009645; and 805\u2009\u00b1\u2009907 in groups 1, 2, and 3, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). For PTNI reconstruction, artificial nerve wrap (ANW) was superior to ANC. Providing collagen scaffold at the nerve defect site enhanced nerve recovery during reconstruction with ANW.<\/jats:p>","DOI":"10.1002\/jbm.b.35369","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T03:54:36Z","timestamp":1704426876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of collagen conduit wrapping with collagen fibers on nerve regeneration in sciatic nerve injury with partial transection: An experimental study in the rat model"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8086-6556","authenticated-orcid":false,"given":"Hiromasa","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Hand Surgery, Graduate School of Medicine Nagoya University  Nagoya City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Graduate School of Medicine Nagoya University  Nagoya City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Graduate School of Medicine Nagoya University  Nagoya City 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