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Though easily and quickly treatable, if gone untreated for too long, UTIs can lead to narrowing of the urethra as well as bladder and kidney infections. Due to the disease potential, it is crucial to mitigate the development of UTIs throughout healthcare. Unfortunately, sexual activity and the use of condoms have been identified as common risk factors for the development of sexually acquired UTIs. Therefore, this study outlines a potential alteration to existing condom technology to decrease the risk of developing sexually acquired UTIs using <jats:italic>S<\/jats:italic>\u2010nitroso\u2010<jats:italic>N<\/jats:italic>\u2010acetylpenicillamine (SNAP), a nitric oxide (NO) donor. Herein, varying concentrations of SNAP are integrated into commercialized condoms through a facile solvent swelling method. Physical characterization studies showed that 72%\u2013100% of the ultimate tensile strength was maintained with lower SNAP concentrations, validating the modified condom's mechanical integrity. Additionally, the evaluation of room\u2010temperature storage stability via NO release analysis outlined a lack of special storage conditions needed compared to commercial products. Moreover, these samples exhibited &gt;90% relative cell viability and &gt;96% bacterial killing, proving biocompatibility and antimicrobial properties. SNAP\u2010Latex maintains the desired condom durability while demonstrating excellent potential as an effective new contraceptive technology to mitigate the occurrence of sexually acquired UTIs.<\/jats:p>","DOI":"10.1002\/jbm.b.35371","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T15:07:55Z","timestamp":1705936075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp><i>S<\/i>\u2010Nitroso\u2010<i>N<\/i><\/scp>\u2010acetylpenicillamine impregnated latex: A new class of barrier contraception for the prevention of intercourse\u2010associated <scp>UTIs<\/scp>"],"prefix":"10.1002","volume":"112","author":[{"given":"Sarah N.","family":"Wilson","sequence":"first","affiliation":[{"name":"School of Chemical, Materials and Biological Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maffe","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials and Biological Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra","family":"Pant","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials and Biological Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan M.","family":"Grommersch","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials and Biological Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-7374","authenticated-orcid":false,"given":"Hitesh","family":"Handa","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials and Biological Engineering, College of Engineering University of Georgia  Athens Georgia USA"},{"name":"Department of Pharmaceutical and Biomedical Sciences College of Pharmacy, University of Georgia  Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2018.32855"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010019\u20100454\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01054-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.5.579"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.12816\/0003256"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00120\u2010011\u20102616\u20105"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Rapid sensor based technology: a novel tool for direct antimicrobial susceptibility testing in urinary tract infection","volume":"2","author":"Kapur S","year":"2014","journal-title":"Transl Med Biotechnol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02986"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010016\u20101310\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11040495"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c01130"},{"key":"e_1_2_8_14_1","unstructured":"National Center for Biotechnology Information.PubChem Compound Summary for Nonoxynol\u20109. 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