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Magnesium phosphate (MgP) is known as an osteoinductive biomaterial because it contains Mg<jats:sup>2+<\/jats:sup> ions and P ions that enhance the activity of osteoplast cells and help in bone regeneration. In this study, MgP and CuO\u2010doped MgP were fabricated and characterized for their physicomechanical properties, particle size, morphology, surface area, antibacterial test, and in vitro bioactivity evaluation using the following techniques: X\u2010rays diffraction, Fourier\u2010transformer infrared, TEM, and Brunauer, Emmett and Teller (BET) surface area, X\u2010rays photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM). Furthermore, these nanopowders were implanted in adult inbred male Wistar rats and studied after two periods (28 and 56\u2009days). The results demonstrated that the obtained semiamorphous powders are in nanoscale (\u2264\u200950\u2009nm). XPS analysis ensured the preparation of MgP as mono MgP and CuO were incorporated in the structure as Cu<jats:sup>2+<\/jats:sup>. The bioactivity was supported by the observation of calcium phosphate layer on the nanopowders' surface. The in vivo study demonstrated success of MgP nanopowders especially those doped with CuO in restoration of calvarial defect bone. Therefore, fabricated biomaterials are of great potential in restoration of bone calvarial defects.<\/jats:p>","DOI":"10.1002\/jbm.b.35376","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T12:45:30Z","timestamp":1706791530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Copper\u2010doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention"],"prefix":"10.1002","volume":"112","author":[{"given":"Sara A. 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