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Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP. Doped HAp has not been used as a carrier for this drug before. The work proved that the prepared carrier\u2010drug system has a particle size of about 130\u2009nm, which indicates its potential for intravenous delivery. In addition, in an acidic environment (imitating cancer cells), the carrier agglomerates allow targeted release of the drug. The drug is evenly distributed, which indicates that the doses released from it will always be comparable. The release of the drug in a neutral environment is long\u2010lasting in controlled doses, whereas in an acidic environment it is immediate. The obtained results indicate the high potential of the material in both slow\u2010release and cancer\u2010targeted release of 6MP.<\/jats:p>","DOI":"10.1002\/jbm.b.35395","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T09:20:36Z","timestamp":1709544036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zinc\u2010doped hydroxyapatite as a <scp>pH<\/scp> responsive drug delivery system for anticancer drug 6\u2010mercaptopurine"],"prefix":"10.1002","volume":"112","author":[{"given":"Marcel","family":"Jakubowski","sequence":"first","affiliation":[{"name":"Institute of Chemical Technology and Engineering Poznan University of Technology  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Majchrzycki","sequence":"additional","affiliation":[{"name":"Institute of Physics, Faculty of Materials Engineering and Technical Physics Poznan 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