{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:10:00Z","timestamp":1789963800733,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["PRELUDIUM 15 [2018\/29\/N\/ST8\/02306]"],"award-info":[{"award-number":["PRELUDIUM 15 [2018\/29\/N\/ST8\/02306]"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Literature data has shown that reactive oxygen species (ROS), generated by immune cells during post\u2010operative inflammation, could induce corrosion of standard Ti\u2010based biomaterials. For Ti\n                    <jats:styled-content style=\"fixed-case\">\uf8ff<\/jats:styled-content>\n                    6Al\n                    <jats:styled-content style=\"fixed-case\">\uf8ff<\/jats:styled-content>\n                    4V alloy, this process can be further accelerated by the presence of albumin. However, this phenomenon remains unexplored for Ti \u03b2\u2010phase materials, such as Ti\uf8ffNb alloys. These alloys are attractive due to their relatively low elastic modulus value. This study aims to address the question of how albumin influences the corrosion resistance of Ti\uf8ffNb alloy under simulated inflammation. Electrochemical and ion release tests have revealed that albumin significantly enhances corrosion resistance over both short (2 and 24\u2009h) and long (2\u2009weeks) exposure periods. Furthermore, post\u2010immersion XPS and cross\u2010section TEM analysis have demonstrated that prolonged exposure to an albumin\u2010rich inflammatory solution results in the complete coverage of the Ti\uf8ffNb surface by a protein layer. Moreover, TEM studies revealed that H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced oxidation and further formation of a defective oxide film were suppressed in the solution enriched with albumin. Overall results indicate that contrary to Ti\n                    <jats:styled-content style=\"fixed-case\">\uf8ff<\/jats:styled-content>\n                    6Al\n                    <jats:styled-content style=\"fixed-case\">\uf8ff<\/jats:styled-content>\n                    4V, the addition of albumin to the PBS\u2009+\u2009H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    solution is not necessary to simulate the harsh inflammatory conditions as could possibly be found in the vicinity of a Ti\uf8ffNb implant.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35404","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T06:26:51Z","timestamp":1711520811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Albumin suppresses oxidation of\n                    <scp>Ti\uf8ffNb<\/scp>\n                    alloy in the simulated inflammatory environment"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-0468","authenticated-orcid":false,"given":"Agata","family":"Sotniczuk","sequence":"first","affiliation":[{"name":"NOMATEN Centre of Excellence National Centre for Nuclear Research  Otwock Poland"},{"name":"Faculty of Materials Science and Engineering Warsaw University of Technology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Kalita","sequence":"additional","affiliation":[{"name":"NOMATEN Centre of Excellence National Centre for Nuclear Research  Otwock Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"Chromi\u0144ski","sequence":"additional","affiliation":[{"name":"NOMATEN Centre of Excellence National Centre for Nuclear Research  Otwock Poland"},{"name":"Faculty of Materials Science and Engineering Warsaw University of Technology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Matczuk","sequence":"additional","affiliation":[{"name":"Chair of Analytical Chemistry, Faculty of Chemistry Warsaw University of Technology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Pisarek","sequence":"additional","affiliation":[{"name":"Laboratory of Surface Analysis Institute of Physical Chemistry, Polish Academy of Sciences  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Garbacz","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering Warsaw University of Technology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109907"},{"key":"e_1_2_9_3_1","volume-title":"Standard Practice for Corrosion Fatigue Testing of Metallic Implant Materials","author":"ASTM F1801\u201097","year":"2014"},{"key":"e_1_2_9_4_1","unstructured":"ASTM F2129.Standard Test Method for Conducting Cyclic Potentiodynamic Polarization Measurements to Determine the Corrosion Susceptibility of Small Implant Devices."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35165"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5006\/2563"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36513"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00882"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37552"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280115"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(89)90019-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2022.110238"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2021.109640"},{"key":"e_1_2_9_16_1","first-page":"702","article-title":"Effect of hydrogen peroxide on titanium surfaces: in situ imaging and step\u2010polarization impedance spectroscopy of commercially pure titanium and titanium, 6\u2010aluminum, 4\u2010vanadium","volume":"67","author":"Bearinger JP","year":"2003","journal-title":"J Biomed Mater Res Part A Off J Soc Biomater Jpn Soc Biomater Aust Soc Biomater Korean Soc Biomater"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-938X(00)00107-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4686(95)00465-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.04.035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.08.013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.046"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2020.154539"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21332-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34182"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2020.108566"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtla.2020.100988"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2022.08.111"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2022.167309"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2022.156282"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110516"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2023.111767"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32836"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2020.108488"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.10.062"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2023.111271"},{"key":"e_1_2_9_36_1","volume-title":"Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications","author":"Brunette DM","year":"2012"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.05.047"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2011.06.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2011.12.022"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1149\/2.033306jes"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2009.10.065"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2013.09.054"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2018.04.120"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioeng.2007.08.007"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1149\/1.3499565"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4332(98)00927-1"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vacuum.2011.03.006"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2023.08.219"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9797(86)90348-6"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2006.02.016"},{"key":"e_1_2_9_51_1","first-page":"221","article-title":"Handbook of X\u2010ray photoelectron spectroscopy","volume":"40","author":"Chastain J","year":"1992","journal-title":"Perkin\u2010Elmer Corp"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10172-012-0183-4"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1067\/mse.2003.22"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.08.017"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-014-8397-7"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2021.127609"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.02.045"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2015.05.071"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2010.12.010"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.07.029"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41529-018-0049-y"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2012.03.008"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.10.039"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<393::AID-JBM14>3.0.CO;2-L"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2021.150364"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:10:19Z","timestamp":1713175819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/jbm.b.35404"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35404","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35404"}}