{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:21:34Z","timestamp":1793215294293,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L\u2010lactide\u2010co\u2010\u03b5\u2010caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate\u2010chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone\u2010derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250\u00b0C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL\/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL\/PEG+BG group. Our findings suggest that the PLCL\/PEG\/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.<\/jats:p>","DOI":"10.1002\/jbm.b.35406","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T16:29:22Z","timestamp":1714235362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Biodegradable electrospun\n                    <scp>poly(L\u2010lactide\u2010co\u2010\u03b5\u2010caprolactone)\/polyethylene glycol\/<\/scp>\n                    bioactive glass composite scaffold for bone tissue engineering"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-4895","authenticated-orcid":false,"given":"Joyce R.","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Cariology, Restorative Sciences and Endodontics University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Dental Materials and Prosthodontics Institute of Science and Technology of S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais M.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics Institute of Science and Technology of S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila T. A.","family":"de Toledo","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry School of Dentistry, S\u00e3o Paulo State University (UNESP)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-1115","authenticated-orcid":false,"given":"Maedeh","family":"Rahimnejad","sequence":"additional","affiliation":[{"name":"Department of Cariology, Restorative Sciences and Endodontics University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia T.","family":"Kito","sequence":"additional","affiliation":[{"name":"Department of Materials Manufacture and Automation Technological Institute of Aeronautics (ITA)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmar P.","family":"Thim","sequence":"additional","affiliation":[{"name":"Department of Materials Manufacture and Automation Technological Institute of Aeronautics (ITA)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago M. B.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre L. S.","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics Institute of Science and Technology of S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2464","authenticated-orcid":false,"given":"Marco C.","family":"Bottino","sequence":"additional","affiliation":[{"name":"Department of Cariology, Restorative Sciences and Endodontics University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Department of Biomedical Engineering College of Engineering, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2019.10.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856206778937244"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2021.1970881"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5147156","article-title":"A 3D\u2010printed PLCL scaffold coated with collagen type i and its biocompatibility","volume":"2018","author":"He Y","year":"2018","journal-title":"Biomed Res Int"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111622"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111588"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2017.01.054"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24173067"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109962"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12020298"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/ac21ab"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37487"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-012-4667-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35315"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.034"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.04.084"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2017.12.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.14295\/bds.2017.v20i4.1495"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnoncrysol.2010.05.076"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jeurceramsoc.2011.09.028"},{"key":"e_1_2_9_22_1","first-page":"140","article-title":"Polycaprolactone\/chlorinated bioglass scaffolds doped with Mg and Li ions: morphological, physicochemical, and biological analysis","volume":"1","author":"Kukulka EC","year":"2022","journal-title":"J Biomed Mater Res B Appl Biomater."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35141"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10965\u2010022\u201003208\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.08.019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101152"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020971"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213761"},{"issue":"1","key":"e_1_2_9_29_1","first-page":"8","article-title":"In situ high\u2010temperature Raman spectroscopy via a remote fiber\u2010optic Raman probe","volume":"72","author":"Zhang B","year":"2023","journal-title":"IEEE Trans Instrum Meas"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/KEM.240-242.217"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm01139h"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2019.11.143"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2007.09.036"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.95290"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110752"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856208784089661"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.12693\/APhysPolA.121.502"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2004.11.012"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass-2015-0010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.09.012"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1589"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35140"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4628(20000509)76:6<947::AID-APP22>3.0.CO;2-5"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2006.03.020"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4075-8"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-0099-y"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2020.1769799"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.04.065"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209386"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.06.016"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2021.0118"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c00626"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2006.07.012"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T12:38:36Z","timestamp":1715776716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,27]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jbm.b.35406"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35406","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,27]]},"assertion":[{"value":"2023-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35406"}}