{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:39Z","timestamp":1753869339319,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009964","name":"Tangshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["22130232H"],"award-info":[{"award-number":["22130232H"]}],"id":[{"id":"10.13039\/501100009964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209028"],"award-info":[{"award-number":["H2023209028"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The dissipative particle dynamics (DPD) simulation was used to study the morphologies and structures of the paclitaxel\u2010loaded PLA\u2010<jats:italic>b<\/jats:italic>\u2010PEO\u2010<jats:italic>b<\/jats:italic>\u2010PLA polymeric micelle. We focused on the influences of PLA block length, PLA\u2010<jats:italic>b<\/jats:italic>\u2010PEO\u2010<jats:italic>b<\/jats:italic>\u2010PLA copolymer concentration, paclitaxel drug content on morphologies and structures of the micelle. Our simulations show that: (i) with the PLA block length increase, the self\u2010assemble structure of PLA\u2010<jats:italic>b<\/jats:italic>\u2010PEO\u2010<jats:italic>b<\/jats:italic>\u2010PLA copolymers with paclitaxel vary between onion\u2010like structure (core\u2010middle layer\u2010shell) to spherical core\u2010shell structure. The PEO shell thins and the size of the PLA core increases. The onionlike structures are comprised of the PEO hydrophilic core, the PLA hydrophobic middle layer, and the PEO hydrophilic shell, the distribution of the paclitaxel drug predominantly occurs within the hydrophobic intermediate layer; (ii) The system forms a spherical core\u2010shell structure when a small amount of the drug is added, and within a certain range, the size of the spherical structure increases as the drug amount increases. When the drug contents (volume fraction) <jats:italic>c<\/jats:italic><jats:sub>drug<\/jats:sub>\u2009=\u200910%, it can be observed that the PLA<jats:sub>4<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PEO<jats:sub>19<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PLA<jats:sub>4<\/jats:sub> spherical structures connect to form rod\u2010shaped structures. With the length of PLA block <jats:italic>N<\/jats:italic><jats:sub>PLA<\/jats:sub>\u2009=\u20098, as the paclitaxel drug concentrations <jats:italic>c<\/jats:italic><jats:sub>drug<\/jats:sub>\u2009=\u20094%, PEO has been insufficient to completely encapsulate the PLA and paclitaxel drug beads. To enhance drug loading capacity while maintaining stability of the system in aqueous solution, the optimal composition for loading paclitaxel is PLA<jats:sub>4<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PEO<jats:sub>19<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PLA<jats:sub>4<\/jats:sub>; the drug content is not higher than 4%; (iii) The paclitaxel\u2010loaded PLA<jats:sub>4<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PEO<jats:sub>19<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PLA<jats:sub>4<\/jats:sub> micelle undergo the transition from onionlike (core\u2010middle layer\u2010shell) to spherical (core\u2010shell) to rod\u2010shaped and lamellar structure as the PLA<jats:sub>4<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PEO<jats:sub>19<\/jats:sub>\u2010<jats:italic>b<\/jats:italic>\u2010PLA<jats:sub>4<\/jats:sub> copolymer concentration increases from <jats:italic>c<\/jats:italic><jats:sub>cp<\/jats:sub>\u2009=\u200910% to 40%.<\/jats:p>","DOI":"10.1002\/jbm.b.35410","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T16:10:12Z","timestamp":1715357412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of morphology and structure of drug\u2010loaded <scp>PLA\u2010<i>b<\/i>\u2010PEO\u2010<i>b<\/i>\u2010PLA<\/scp> polymeric micelle: A dissipative particle dynamics simulations study"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-7412","authenticated-orcid":false,"given":"Dongmei","family":"Liu","sequence":"first","affiliation":[{"name":"School of Science North China University of Science and Technology  Tangshan PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Science North China University of Science and Technology  Tangshan PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danping","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Science North China University of Science and Technology  Tangshan PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchao","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Science North China University of Science and Technology  Tangshan PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Science North China University of Science and Technology  Tangshan PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909509031919"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(01)00986\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(93)92789\u2010V"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14214702"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2021.110325"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310588"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12030434"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.12.024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2008.07.121"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM01559G"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128245"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1081\/PDT\u2010120018484"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3866\/PKU.WHXB201603071"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v11i5.20"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123610"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.24255"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2021.123511"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/la950649v"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm501519u"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.10.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2009.04.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.08.022"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2007.01.013"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma101132n"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2SM26200B"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie2014668"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp407529u"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/am503920m"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.09.049"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b08366"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.12.027"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b03833"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.01.033"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fluid.2022.113598"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13091516"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13172866"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07671J"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA08936F"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA00940D"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10965\u2010014\u20100452\u20101"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1209\/0295\u20105075\/19\/3\/001"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.474784"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/la000010d"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.476300"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000119"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.29278"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201600277"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T16:38:11Z","timestamp":1715791091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jbm.b.35410"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35410","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"type":"print","value":"1552-4973"},{"type":"electronic","value":"1552-4981"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35410"}}