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Additionally, such scaffolds must be biocompatible to prevent the transplanted matrix from taking a toll on the patient's body. From the viewpoint of structure and bio\u2010absorbability, a \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) fiber scaffold (\u03b2TFS) is expected to serve as a good scaffold for tissue engineering. However, the fragility and high solubility of \u03b2\u2010TCP fibers make this matrix unsuitable for long\u2010term cell culture. To solve this problem, we developed an alginate\u2010coated \u03b2\u2010TCP fiber scaffold (\u03b2TFS\u2010Alg). To assess cell proliferation and differentiation in the presence of \u03b2TFS\u2010Alg, we characterized ATDC5 cells, a chondrocyte\u2010like cell line, when grown in this matrix. We found that alginate coated the surface of \u03b2TFS fiber and suppressed the elution of Ca<jats:sup>2+<\/jats:sup> from \u03b2\u2010TCP fibers. Due to the decreased solubility of \u03b2TFS\u2010Alg compared with \u03b2\u2010TCP, the former provided an improved scaffold for long\u2010term cell culture. Additionally, we observed superior cell proliferation and upregulation of chondrogenesis marker genes in ATDC5 cells cultured in \u03b2TFS\u2010Alg. 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