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In this study, we show that X\u2010ray microfocus computed tomography (microCT) presents a key added value to visualize degradation mode and to evaluate degradation rate and material surface properties in 3D and at high resolution of large regions of interest. The in vitro degradation behavior of three candidate biodegradable stent materials was evaluated: pure iron (Fe), pure zinc (Zn), and a quinary Zn alloy (Zn\uf8ffAg\uf8ffCu\uf8ffMn\uf8ffZr). These metals were compared to a reference biostable cobalt\uf8ffchromium (Co\uf8ffCr) alloy. To compare the degradation mode and degradation rate evaluated with microCT, scanning electron microscopy (SEM) and inductively\u2010coupled plasma (ICP) were included. We confirmed that Fe degrades very slowly but with desirable uniform surface corrosion. Zn degrades faster but exhibits localized deep pitting corrosion. The Zn alloy degrades at a similar rate as the pure Zn, but more homogeneously. However, the formation of deep internal dendrites was observed. Our study provides a detailed microCT\u2010based comparison of essential surface and corrosion properties, with a structural characterization of the corrosion behavior, of different candidate stent materials in 3D in a non\u2010destructive way.<\/jats:p>","DOI":"10.1002\/jbm.b.35452","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T21:19:11Z","timestamp":1721769551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the biodegradability of candidate metallic intravascular stent materials using <scp>X\u2010ray<\/scp> microfocus computed tomography: An in vitro study"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-4327","authenticated-orcid":false,"given":"Lisa","family":"Leyssens","sequence":"first","affiliation":[{"name":"Mechatronic, Electrical Energy and Dynamic Systems Institute of Mechanics, Materials, and Civil 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