{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:24:37Z","timestamp":1773073477079,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is a bacteria\u2010induced chronic inflammatory disease characterized by degradation of the supporting tissue and bone in the oral cavity. Treatment modalities seek to facilitate periodontal rehabilitation while simultaneously preventing further gingival tissue recession and potentially bone atrophy. The aim of this study was to compare two differently sourced membranes, a resorbable piscine collagen membrane and a porcine\u2010derived collagen membrane, in the repair of soft tissue defects utilizing a preclinical canine model. This in vivo component consisted of 10 beagles which were subjected to bilateral maxillary canine mucogingival flap defects, as well as bilateral soft tissue defects (or pouches) with no periodontal ligament damage in the mandibular canines. Defects received either a piscine\u2010derived dermal membrane, (Kerecis\u00ae Oral, \u00cdsafj\u00f6r\u00f0ur, Iceland) or porcine\u2010derived dermal membrane (Geistlich Mucograft\u00ae, Wolhusen, Switzerland) in a randomized fashion (to avoid site bias) and were allowed to heal for 30, 60, or 90\u2009days. Statistical evaluation of tissue thickness was performed using general linear mixed model analysis of variance and least significant difference (LSD) post hoc analyses with fixed factors of time and membrane. Semi\u2010quantitative analysis employed for inflammation assessment was evaluated using a chi\u2010squared test along with a heteroscedastic <jats:italic>t<\/jats:italic>\u2010test and values were reported as mean and corresponding 95% confidence intervals. In both the mucogingival flap defects and soft tissue gingival pouches, no appreciable qualitative differences were observed in tissue healing between the membranes. Furthermore, no statistical differences were observed in the thickness measurements between piscine\u2010 and porcine\u2010derived membranes in the mucogingival flap defects (1.05\u2009mm [\u00b10.17] and 1.29\u2009mm [\u00b10.17], respectively [<jats:italic>p<\/jats:italic>\u2009=\u2009.06]) or soft tissue pouches (1.36\u2009mm [\u00b10.14] and 1.47\u2009mm [\u00b10.14], respectively [<jats:italic>p<\/jats:italic>\u2009=\u2009.27]), collapsed over time. Independent of membrane source (i.e., piscine or porcine), similar inflammatory responses were observed in both the maxilla and mandible at the three time points (<jats:italic>p<\/jats:italic>\u2009=\u2009.88 and <jats:italic>p<\/jats:italic>\u2009=\u2009.79, respectively). Histologic and histomorphometric evaluation results indicated that both membranes yielded equivalent tissue responses, remodeling dynamics and healing patterns for the mucogingival flap as well as the soft tissue gingival pouch defect models.<\/jats:p>","DOI":"10.1002\/jbm.b.35468","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:51:19Z","timestamp":1723783879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preclinical evaluation of mucogingival defect treatment using piscine membranes: An in vivo assessment of wound healing"],"prefix":"10.1002","volume":"112","author":[{"given":"Derek S.","family":"Sheinberg","sequence":"first","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Almada","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Adult Dentistry, Faculty of Dentistry Universidad de La Frontera  Temuco Chile"},{"name":"Center of Excellence in Morphological and Surgical Studies (CEMyQ), Faculty of Medicine Universidad de La Frontera  Temuco Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaire V.","family":"Slavin","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Mirsky","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasudev Vivekanand","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Tovar","sequence":"additional","affiliation":[{"name":"Biomaterials Division NYU Dentistry  New York New York USA"},{"name":"Department of Oral and Maxillofacial Surgery New York University, Langone Medical Center and Bellevue Hospital Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"additional","affiliation":[{"name":"Biomaterials Division NYU Dentistry  New York New York USA"},{"name":"Department of Biomedical Engineering, NYU Tandon School of Engineering  Brooklyn New York USA"},{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery, NYU Grossman School 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