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This study presents a modified BG series (42SiO<jats:sub>2<\/jats:sub>\u2014<jats:italic>x<\/jats:italic>TiO<jats:sub>2<\/jats:sub>\u201424Na<jats:sub>2<\/jats:sub>O\u201421CaO\u201413P<jats:sub>2<\/jats:sub>O<jats:sub>5<\/jats:sub>, where <jats:italic>x<\/jats:italic>\u2009=\u20098 and 16 TiO<jats:sub>2<\/jats:sub>). TiO<jats:sub>2<\/jats:sub> replaced the SiO<jats:sub>2<\/jats:sub> concentration in the glass and was incorporated due to its biocompatibility and influence on glass structure. Material characterization determined that TiO<jats:sub>2<\/jats:sub> did not induce crystallization within the glass but did increase the glass transition temperature (<jats:italic>T<\/jats:italic><jats:sub><jats:italic>g<\/jats:italic><\/jats:sub>) from 520\u00b0C to 600\u00b0C thereby indicating a more stable network connectivity. Scaffolds were synthesized using the foam replication method, resulting in scaffolds with a pore size of approximately 500\u2009\u03bcm with the <jats:italic>BG\u20104<\/jats:italic> composition (30SiO<jats:sub>2<\/jats:sub>\u201412TiO<jats:sub>2<\/jats:sub>\u201424Na<jats:sub>2<\/jats:sub>O\u201421CaO\u201413P<jats:sub>2<\/jats:sub>O<jats:sub>5<\/jats:sub>) retaining its amorphous character post\u2010heat treatment. Scaffold ion release was monitored over 5\u201360\u2009days in simulated body fluid (SBF). Si<jats:sup>4+<\/jats:sup> release was found to decrease, while Ca<jats:sup>2+<\/jats:sup> levels increased in SBF as TiO<jats:sub>2<\/jats:sub> replaced SiO<jats:sub>2<\/jats:sub> within the glass series. Cytocompatibility studies revealed that MC3T3 Osteoblast cells proliferated on the <jats:italic>BG\u20104<\/jats:italic> scaffold surface and at its interface within culture media, and cell numbers were not significantly reduced.<\/jats:p>","DOI":"10.1002\/jbm.b.35497","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:58:51Z","timestamp":1730987931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mimicking the Architecture and Dissolution Chemistry of Cancellous Bone Tissue to Optimize the Biocompatibility of Bioactive Scaffolds"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-9558","authenticated-orcid":false,"given":"Lindsay","family":"Piraino","sequence":"first","affiliation":[{"name":"Inamori School of Engineering, Alfred University  Alfred New York 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