{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:25:21Z","timestamp":1784582721771,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["956621"],"award-info":[{"award-number":["956621"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Biliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%\u201360% of complications. While current stent\u2010based devices on the market show promising results in reducing complications, they are manufactured from permanent synthetic materials and require a second reintervention for their removal. This exposes the patients to other potential complications and increases healthcare costs. This study develops a fabrication technique to produce a bioabsorbable biliary stent based on silk fibroin. The process used a dip\u2010coating procedure for silk fibroin that produced highly smooth monolayer tubular specimens without the use of any additional surfactants during removal. This process was combined with an electrospinning step to produce bilayer structures through the deposition of electrospun silk fibroin on the outer surface. The structures proved to have promising mechanical, morphological, and cytocompatibility properties for use in the field of biliary stenting. Furthermore, the technique investigated proved to be reproducible, achieving an important requirement for large\u2010scale use even in the presence of a biomaterial derived from a natural source. These results show the possibility of obtaining a completely bioabsorbable internal biliary stent that does not require any second reintervention. This study can be the starting point for further investigations both in\u00a0vitro and in\u00a0vivo to assess the suitability of silk fibroin biliary stents for clinical applications.<\/jats:p>","DOI":"10.1002\/jbm.b.35499","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T19:18:28Z","timestamp":1738178308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-4032","authenticated-orcid":false,"given":"Benedetta","family":"Isella","sequence":"first","affiliation":[{"name":"Biomechanics Research Centre (BioMEC), School of Engineering, College of Science and Engineering, Institute for Health Discovery and Innovation, University of Galway  Galway Ireland"},{"name":"Fibrothelium GmbH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine University Hospital Cologne  Cologne Germany"},{"name":"Faculty of Medicine Institute for Laboratory Animal Science and Experimental Surgery, University of Aachen Medical Centre, RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Drinic","sequence":"additional","affiliation":[{"name":"Fibrothelium GmbH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman M.","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute for Laboratory Animal Science and Experimental Surgery, University of Aachen Medical Centre, RWTH Aachen University  Aachen Germany"},{"name":"Department of Plastic, Aesthetic, and Hand Surgery St. Antonius Hospital Eschweiler  Eschweiler Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted J.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Biomechanics Research Centre (BioMEC), School of Engineering, College of Science and Engineering, Institute for Health Discovery and Innovation, University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kopp","sequence":"additional","affiliation":[{"name":"Fibrothelium GmbH  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2bm00234e"},{"key":"e_1_2_12_3_1","first-page":"1","article-title":"Causes and Trends in Liver Disease and Hepatocellular Carcinoma Among Men and Women Who Received Liver Transplants in the U.S., 2010\u20132019","volume":"15","author":"Wang S.","year":"2020","journal-title":"PLoS One"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-018-1669-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2017.03.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.04.069"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-022-05479-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.06.019"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.01.043"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.056"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14383"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.09.039"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34709"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.04.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.12.025"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170935"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0707-y"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010016\u20100538\u20105"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2020.100593"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00661"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328219888841"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31641"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.1040"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110742"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01584A"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110994"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12571"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130374"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328219836625"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB01310A"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.622220"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.03.028"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2013.39.2.43"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.03.059"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2018-228"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00957"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.043"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2020-000510"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12122936"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-0947-2_7"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.585077"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078020\u2010y"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01482"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1163\/092050609X12586381656530"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2019.108077"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm101422j"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857097064.2.330"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212982"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800465"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.01.020"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.08.008"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900234"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.06.010"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2018.12.020"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200062a"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.664306"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2777"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.2.3.2"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282211051501"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.measurement.2021.109265"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.08.021"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15103735"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.11.059"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.11.011"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-34062-5.00008-X"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2015.03.012"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00160-X"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01773"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13233-011-0208-2"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200521"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.037"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200500137"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:03:31Z","timestamp":1753254211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jbm.b.35499"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35499","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"2024-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35499"}}