{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:35Z","timestamp":1786977875378,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Treating severe bone deformities and abnormalities continues to be a major clinical hurdle, necessitating the adoption of suitable materials that can actively stimulate bone regeneration. Magnesium phosphate (MP) is a material that has the ability to stimulate the growth of bones. The current study involved the synthesis of mesoporous MP and lanthanum (La)\u2010doped nanopowders using a chemical precipitation approach. The nanopowders were analyzed using several techniques, including XRD, FTIR, HR\u2010TEM, BET, XPS, and FE\u2010SEM. The results confirmed the nanopowders' size of less than 40\u2009nm and the successful incorporation of La\n                    <jats:sup>3+<\/jats:sup>\n                    ions into the MP structure. The bioactivity of the materials was assessed in\u00a0vitro using simulated bodily fluid (SBF) at 37\u00b0C for a duration of 14\u2009days in a shaker incubator (50\u2009rpm). The SEM showed that a bone\u2010like apatite layer formed quickly on the nanopowders' surface, proving that they have unique bioactive properties. The EDX spectra confirmed the presence of Ca, P, Mg, and La elements after immersion in SBF. The MP nanopowders, both with and without La doping, demonstrated the capacity to stimulate bone formation in a rat femoral bone defect model over a 28\u2010day duration. Radiographic and histological studies showed that the La\u2010doped MP nanopowders greatly improved bone repair and regeneration in comparison to the La\u2010free nanopowders. Finally, the readily producible mesoporous MP nanomaterials, especially those with increased La doping (up to 7\u2009wt%), exhibit significant potential for the restoration of large bone defects. Hence, fabricated nanopowders have immense promise for repairing bone criterion defects.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35515","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:35:07Z","timestamp":1734669307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mesoporous Lanthanum\u2010Doped Magnesium Phosphate Nanopowders Promote Healing of Critical\u2010Size Bone Defects: An In\u00a0Vivo Study"],"prefix":"10.1002","volume":"113","author":[{"given":"Mona","family":"Moaness","sequence":"first","affiliation":[{"name":"Refractories, Ceramics and Building Materials Department Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"ElShebiney","sequence":"additional","affiliation":[{"name":"Department of Narcotics, Ergogenics and Poisons Medical Research and Clinical Studies Institute, National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan H.","family":"Beherei","sequence":"additional","affiliation":[{"name":"Refractories, Ceramics and Building Materials Department Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-6762","authenticated-orcid":false,"given":"Mostafa","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Refractories, Ceramics and Building Materials Department Advanced Materials Technology and Mineral Resources Research Institute, National Research Centre  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605x\/ac2886"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2023.05.133"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra02311d"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.03.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534\u2010018\u20100121\u20107"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010018\u20100411\u20109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2008.10.043"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.05.026"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21932"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010012\u20109486\u20106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.04.186"},{"key":"e_1_2_11_14_1","volume-title":"Bancrofts Theory and Practice of Histological Techniques","author":"Banchroft J. 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