{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:11:35Z","timestamp":1778609495709,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The bioactive glass\u2013ceramic spacer (BGS)\u20107, a biosynthetic intervertebral fusion material introduced in 2014, has not been the subject of comparative clinical studies on anterior cervical discectomy and fusion (ACDF) surgery. This study, for the first time, aims to compare the radiological and clinical outcomes of the renewed BGS\u20107, released in 2019, with those of an allograft spacer. The comparison includes a finite element analysis of the biomechanical properties of each implant, adding a novel dimension to the research. We prospectively followed up on 29 patients who underwent ACDF using BGS\u20107 as the experimental group. To select a control group for comparison, 253 patients with level 1 ACDF with an allograft spacer between 2012 and 2022 were selected from our hospital. Using propensity score matching, 27 and 54 patients in the BGS\u20107 and allograft groups, respectively, were selected. The average subsidence length was 1.02\u2009\u00b1\u20091.44\u2009mm per level in the BGS\u20107 group and 2.27\u2009\u00b1\u20092.25\u2009mm per level in the allograft group. Subsidence was observed in 14 of 54 patients (25.9%) in the allograft group and one of 27 patients (3.7%) in the BGS\u20107 group (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). In the allograft group, 16 of the 54 patients (29.6%) monitored for 6\u2009months achieved satisfactory fusion outcomes with grades 4 and 5. Thirty\u2010eight of 54 patients (70.4%) followed up for &gt;\u20091\u2009year in the allograft group achieved adequate fusion outcomes with grades 4 and 5. In the BGS\u20107 group, 17 of the 27 patients (63.0%) monitored for 6\u2009months achieved satisfactory fusion results with grades 4 and 5. Twenty\u2010three of the 27 patients (85.2%) followed up for &gt;\u20091\u2009year obtained adequate fusion outcomes with grades 4 and 5. There was a significant difference in the fusion rates between the two groups at 6\u2009months (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). BGS\u20107 is a reliable instrument for ACDF with no instances of instrumental failure. The BGS\u20107 group had positive clinical outcomes after surgery without any untoward events, and an early fusion rate with the creation of a bone bridge was noted during the 6\u2010month follow\u2010up period. Our findings not only indicate the safety of BGS\u20107 but also its practicality as a substitute for allografts in ACDF, instilling confidence in its application.<\/jats:p>","DOI":"10.1002\/jbm.b.35521","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:29:27Z","timestamp":1734686967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Outcomes After Anterior Cervical Discectomy and Fusion Using Bioactive Glass\u2013Ceramic Spacer\u20107 (<scp>NOVOMAX<\/scp>\u2010<scp>FUSION<\/scp>) and an Allograft Spacer: A Retrospective, Case\u2010Matched, Multicenter Study"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-7477","authenticated-orcid":false,"given":"Gi\u2010Wuk","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"},{"name":"Department of Neurosurgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Ah","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Neurosurgery Severance Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Joon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Severance Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Kyu","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"},{"name":"Department of Neurosurgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"},{"name":"Department of Neurosurgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Wook","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of Korea"},{"name":"Department of Neurosurgery Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong\u2010Ju","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine and Spinal Cord Institute Gangnam Severance Spine Hospital  Seoul Republic of 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