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Owing to their versatility, hydrogels can be loaded with various functional factors, making them promising wound dressings. However, many hydrogel dressings cannot support cell survival for a long time, thereby delaying the process of tissue repair. Herein, based on chitosan (CS)\/alginate (SA)\/poly(ethylene glycol) diacrylate (PEGDA), a basic hydrogel with hemostasis and antibacterial properties was prepared, and loaded with vascular endothelial cadherin (VE\u2010cadherin) and fibroblast growth factors (FGF) to promote the co\u2010culture of various skin cells, suitable for treating various skin injury types: (1) Construct a three\u2010dimensional microenvironment conducive to the release of drugs and factors using natural biological macromolecules CS\/SA. (2) Promote the cell growth by loading growth factors. (3) Establish skin burn models of different degrees and observe the repair process. From the results, the 3D microenvironment provided by hydrogel could support the active growth of cells for 12\u2009days. Furthermore, deep burns with full\u2010thickness skin were substantially repaired within about 24\u2009days. Collectively, CS\/SA hydrogel containing VE\u2010cadherin and FGF can promote tissue healing in wounds with necrotic tissue, making it an ideal candidate for burn treatment.<\/jats:p>","DOI":"10.1002\/jbm.b.35533","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T04:23:49Z","timestamp":1736396629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chitosan\/Alginate\u2010Based Hydrogel Loaded With <scp>VE<\/scp>\u2010Cadherin\/<scp>FGF<\/scp> as Scaffolds for Wound Repair in Different Degrees of Skin Burns"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-2129","authenticated-orcid":false,"given":"Sainan","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry School of Materials Science and Engineering, Southwest Jiaotong University  Chengdu 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