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In this work, PRP was incorporated into injectable compositions of alginate\u2010based hydrogel and evaluated in\u00a0vitro and in\u00a0vivo. In\u00a0vitro tests revealed that PRP addition promoted cell adhesion, cell proliferation, and distribution of seeded fibrochondrocytes on the hydrogel. Further, the DNA quantification and sGAG estimation confirmed the production of fibrocartilage\u2010specific extracellular matrix, predominantly type 1 collagen and sGAG. For in\u00a0vivo evaluation, tears were created surgically in the rabbit menisci and were filled with injectable hydrogel. Sham and hydrogel without PRP were used as controls. Histopathological evaluation after 3\u2009months of implantation revealed that the healing was partial for sham control, but complete for hydrogel without PRP. The hydrogel served as the scaffold for fibrocartilage tissue regeneration. On the other hand, PRP\u2010incorporated hydrogel showed good healing with low signs of inflammation as evidenced by histology and biochemical content. The healing was complete, and the nature of the regenerated tissues was very close to native tissue indicating that alginate\u2010based hydrogel is a promising candidate for meniscal tissue repair.<\/jats:p>","DOI":"10.1002\/jbm.b.35541","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T12:44:22Z","timestamp":1738413862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Platelet\u2010Rich Plasma Loaded Alginate\u2010Based Injectable Hydrogel for Meniscal Tear Repair: In\u00a0Vivo Evaluation in Lapine Model"],"prefix":"10.1002","volume":"113","author":[{"given":"Rajalekshmi","family":"Resmi","sequence":"first","affiliation":[{"name":"Division of Polymeric Medical Devices, Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasree","family":"Parvathy","sequence":"additional","affiliation":[{"name":"Corporate R&amp;D Center, HLL Life Care Limited  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Anjali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Kerala  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Amrita","sequence":"additional","affiliation":[{"name":"Department of Applied Biology, Biomedical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences and Technology  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Jyothi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Sree Uthradom Thirunal (SUT) Hospital  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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