{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:08:20Z","timestamp":1791972500411,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014903","name":"Osteo Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Preclinical testing of tissue engineering modalities are commonly performed in a healthy wound bed. These conditions do not represent clinically relevant compromised oral wound environments due to radiation treatments seen clinically. This study aimed to characterize the bone regeneration outcomes in critical\u2010sized mandibular defects using particulate grafting in an irradiated preclinical model of compromised wound healing. Sixteen New Zealand white rabbits were divided into two groups (<jats:italic>n<\/jats:italic>\u2009=\u20098\/group), namely (i) irradiated (experimental) and (ii) non\u2010irradiated (control). The rabbits in the experimental group received a total of 36\u2009Gy radiation, followed by surgical intervention to create critical\u2010sized (10\u2009mm), full\u2010thickness mandibular defects. The control group was subjected to the same surgical intervention. All defects were filled with bovine bone grafting material (Bio\u2010Oss, Geistlich, Princeton, NJ, USA) and allowed to heal for 8\u2009weeks. At the study endpoint, rabbits were euthanized, and their mandibles were harvested for micro\u2010computed tomographic, histological, and histomorphometric processing and analysis. Qualitative histological analysis revealed increased levels of bone formation and bridging in the control group relative to the experimental group. This was accompanied by increased levels of soft tissue presence in the experimental group. Volumetric reconstruction showed a significantly higher degree of bone in the control group (27.59%\u2009\u00b1\u20092.71), relative to the experimental group (22.02%\u2009\u00b1\u20092.71) (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). The irradiated rabbit model exhibited decreased bone regeneration capacity relative to the healthy subjects, highlighting its suitability as a robust compromised wound healing environment for further preclinical testing involving growth factors or customized, high\u2010fidelity 3D printed tissue engineering scaffolds.<\/jats:p>","DOI":"10.1002\/jbm.b.35556","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:37:44Z","timestamp":1741754264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Compromised Maxillofacial Wound Healing Model for Characterization of Particulate Bone Grafting: An In\u00a0Vivo Study in Rabbits"],"prefix":"10.1002","volume":"113","author":[{"given":"Nourhan","family":"Hussein","sequence":"first","affiliation":[{"name":"Katz Department of Oral and Maxillofacial Surgery The University of Texas Health Science Center at Houston School of Dentistry  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-0339","authenticated-orcid":false,"given":"Vasudev Vivekanand","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute (BioNIUM) University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraja","family":"Dharmaraj","sequence":"additional","affiliation":[{"name":"Katz Department of Oral and Maxillofacial Surgery The University of Texas Health Science Center at Houston School of Dentistry  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Mirsky","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Norton","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Ramagli","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Tailor","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-4373","authenticated-orcid":false,"given":"F. Kurtis","family":"Kasper","sequence":"additional","affiliation":[{"name":"Department of Orthodontics The University of Texas Health Science Center at Houston School of Dentistry  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute (BioNIUM) University of Miami  Miami Florida USA"},{"name":"DeWitt Daughtry Family Department of Surgery, Division of Plastic Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"additional","affiliation":[{"name":"Biomaterials and Regenerative Biology Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Biomedical Engineering NYU Tandon School of Engineering  Brooklyn New York USA"},{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-7083","authenticated-orcid":false,"given":"Simon","family":"Young","sequence":"additional","affiliation":[{"name":"Katz Department of Oral and Maxillofacial Surgery The University of Texas Health Science Center at Houston School of Dentistry  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-398358-9.00071-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tdj.2015.05.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70058-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4585401"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2011.11.022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2018.0361"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(96)01880-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2017.04.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.08.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2017.05.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.03.017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198604000-00036"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.10.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200010000-00015"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2008.01.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182865c57"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22351"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.04.024"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12939"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2021.06.006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2022.2013568"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80988-X"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210150"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.03.014"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00915-3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.01.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2017.10.027"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0186"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01279"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04679-8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122289"},{"issue":"2","key":"e_1_2_10_38_1","first-page":"270e","article-title":"Engineering 3D Printed Bioceramic Scaffolds to Reconstruct Critical\u2010Sized Calvaria Defects in a Skeletally Immature Pig Model","volume":"152","author":"DeMitchell\u2010Rodriguez E. M.","year":"2023","journal-title":"Plastic and Reconstructive Surgery"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T17:38:45Z","timestamp":1744393125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jbm.b.35556"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35556","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35556"}}