{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:45:25Z","timestamp":1790246725263,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In recognizing the critical role of vitamin D in bone metabolism and osseointegration, research aims to identify whether preoperative vitamin D deficiency serves as a risk factor for early implant failure. By analyzing patient outcomes and their serum vitamin D levels, studies seek to establish evidence\u2010based recommendations for vitamin D assessment and management in the preoperative period, with the ultimate goal of enhancing implant success rates and patient outcomes in dental implantology. Given these insights, it is important for clinicians to incorporate the preoperative evaluation of vitamin D serum levels into their standard protocol for patients undergoing dental implant procedures. The objective of this study is to review and investigate the correlation between early dental implant failure (EDIF) and reduced serum levels of vitamin D, and to evaluate the potential benefits of preoperative screening and supplementation of vitamin D in patients undergoing dental implant surgery. A literature review was performed using a selected database\u2014PubMed, Google Scholar, Cochrane, and SCOPUS\u2014to assess the effect of vitamin D3 level on EDIF and biological factors (i.e., peri\u2010implant bone level). Studies were limited to peer\u2010reviewed, indexed journals. Subsequently, a hypothesis was proposed that vitamin D3 supplementation would mitigate the negative effect of vitamin D3 deficiency. The potential benefit of vitamin D3 supplementation\u2014systemic and topical\u2014was assessed in terms of bone\u2010to\u2010implant contact (BIC) and peri\u2010implant bone level. The deleterious effects of low vitamin D serum levels on osseointegration of dental implants and immune system modulation are increasingly accepted. Evidence has displayed that deficiency of this vitamin can result in impaired peri\u2010implant bone formation. Vitamin D deficiency resulted in nearly a fourfold increase in overall EDIF incidence. Presurgical supplementation of vitamin D3 demonstrated increased levels of implant osseointegration, increased bone\u2013implant contact, enhanced bone level maintenance, and decreased EDIF even in at\u2010risk demographics (i.e., diabetic subjects). The findings of this study reinforce the role of vitamin D in dental implant osseointegration. Our study, particularly, emphasizes the necessity of vitamin D supplementation for individuals with sub\u2010physiologic vitamin D serum levels (\u2264\u200930\u2009ng\/mL) and those within specific risk categories: smokers, diabetics, obese individuals, and those with compromised immune systems. Adopting a proactive management plan, including screening and supplementation in these patients, may substantially enhance the clinical outcomes in dental implant surgery.<\/jats:p>","DOI":"10.1002\/jbm.b.35558","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:58:28Z","timestamp":1740049108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin D Screening and Supplementation\u2014A Novel Approach to Higher Success: An Update and Review of the Current Literature"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2831-1182","authenticated-orcid":false,"given":"Thomas G.","family":"Wiedemann","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, NYU Dentistry  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5024-7972","authenticated-orcid":false,"given":"Hyun Woo","family":"Jin","sequence":"additional","affiliation":[{"name":"BA\/DDS Joint Program, NYU Dentistry  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, NYU Langone Health\/Bellevue Hospital Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"additional","affiliation":[{"name":"Biomaterials Division\u2014NYU Dentistry  New York New York USA"},{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery \u2010 NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Biomedical Engineering\u2014NYU Tandon School of Engineering  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huzefa S.","family":"Talib","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, NYU Dentistry  New York New York 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