{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:02:18Z","timestamp":1784631738613,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009055","name":"\u00c7anakkale Onsekiz Mart \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Donor\u2010side morbidity of autografting for maxillofacial region defect regeneration has directed attention to bioengineered scaffolds. Composite scaffolds that mimic the bone\u00a0extracellular matrix (ECM) are the potential candidates for defect reconstruction. Herein, a plant\u2010based regenerative hydrogel, quince seed mucilage (QSM), was enriched with the nanohydroxyapatite (nHAp) particles to construct composite scaffolds (QSM\/nHAp). The emerging scaffold is able to induce cellular spheroid formation and regenerate the critical\u2010sized bilateral mandibular defects in rabbits. The macroscopic observations, histochemical (HC) and immunohistochemical (IHC) stainings, \u03bc\u2010computer tomography (CT) scanning, quantitative real time\u2010polymerase chain reaction (qRT\u2010PCR) analyses, and scanning electron microscopy (SEM) imaging revealed that all QSM\/nHAp scaffolds were swelled with host blood, filled the whole cavity, and sustained cellular infiltration without adverse reactions. The gradual biodegradation profile of the scaffolds improved bone regeneration by releasing nHAp particles from the scaffold. Strikingly, co\u2010development of dental and bone regeneration was observed for all QSM\/nHAp groups beginning after day 21. Moreover, QSM\/nHAp scaffolds induced expression (&gt;\u20092\u2010fold) of bone and dental\u2010related gene and protein expressions at the grafted area and sustained a proper platform for maxillofacial remodeling. Therefore, we strongly believe that such biocompatible plant\u2010based constructs, compared with conventional medical devices used in maxillofacial surgery, could support and induce simultaneous bone and dental regeneration due to the intrinsic dynamics of the material.<\/jats:p>","DOI":"10.1002\/jbm.b.35570","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T02:41:54Z","timestamp":1743302514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage\u2010Nanohydroxyapatite Scaffolds in Rabbit Mandibles"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6745-3790","authenticated-orcid":false,"given":"Cigdem","family":"Cetin Genc","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry, \u00c7anakkale Onsekiz Mart University  \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal Deniz","family":"Y\u0131lmaz\u2010Dagdeviren","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Engineering Faculty, Izmir Institute of Technology  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Radiology Faculty of Dentistry, \u00c7anakkale Onsekiz Mart University  \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Derkus","sequence":"additional","affiliation":[{"name":"Stem Cell Research Lab., Department of Chemistry Faculty of Science, Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpin","family":"Degirmenci","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry, \u00c7anakkale Onsekiz Mart University  \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz Emre","family":"Arslan","sequence":"additional","affiliation":[{"name":"Regenerative Biomaterials Laboratory, Department of Bioengineering Faculty of Engineering, \u00c7anakkale Onsekiz Mart University  \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001115"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300128"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14102558"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2021.05.089"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12040905"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0503"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11064"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S299641"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044620\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst11020149"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.01.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12020212"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44164\u2010023\u201000049\u2010w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bprint.2020.e00127"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9gc02391g"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818415-8.00002-4"},{"key":"e_1_2_10_19_1","first-page":"127","volume-title":"Functional Biopolymers. Polymers and Polymeric Composites: A Reference Series","author":"Hussain M. A.","year":"2019"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2013.08.030"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222\u20101808(15)60934\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.06.016"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.12.054"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.03.096"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.10.008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883911520918390"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01184K"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2020.11.008"},{"key":"e_1_2_10_29_1","volume-title":"Novel Biomaterials for Regenerative Medicine\/ Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue\u2010Regeneration (p. 533)","author":"ChuRoqia A.","year":"2018"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3bm00170a"},{"key":"e_1_2_10_31_1","unstructured":"Guidelines A \u201cThe ARRIVE Guidelines 2.0 \u201dn.d."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.244"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090310"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102613.2000.00163.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.103020"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36399"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010019\u201002046\u20102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100267"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010018\u20106030\u2010z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.103532"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104831"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010013\u20109726\u20101"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2018.04.021"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2011.02168.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677214540635"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\u2010journals\u201010024\u20102306"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510366899"},{"issue":"3","key":"e_1_2_10_49_1","first-page":"1554","article-title":"Histomorphological Study of Dentine Pulp Complex of Continuously Growing Teeth in the Rabbits","volume":"9","author":"Ali Z. H.","year":"2012","journal-title":"Life Science Journal"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:10:55Z","timestamp":1754907055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jbm.b.35570"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35570","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"assertion":[{"value":"2024-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35570"}}