{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:09:39Z","timestamp":1792206579348,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Dentin hypersensitivity (DH) prevalence ranges from 72.5%\u201398% and is common from the third decade of life. Despite the variety of products available, dentine hypersensitivity remains a persistent issue. From the vast array of existing products, ceramics specifically Calcium sodium phosphosilicate (CSPS) based glasses seem to be the most versatile material to manage dentin hypersensitivity. Literature clearly indicates that Calcium sodium phosphosilicate (CSPS) permits a multitude of possibilities as it allows integration with soft and hard tissues. The ability to generate a flexible structure has resulted in an array of modifications. These characteristics are most vital and target specific to dentin than other biomaterials. Developing a long\u2010lasting cure for dentin caries and dentin hypersensitivity will significantly improve the quality of life for patients. Even though it has been used for dentin remineralization for over two decades, CSPS has been able to achieve only partial success in terms of strength and crystalline pattern. CSPS can be put into more effective use in terms of dentin remineralization by in\u2010depth understanding of the dynamic matrisome and the mineralization process. CSPS can be optimized as a smart delivery method and applied as a sealant for pits and fissures in a comprehensive preventive dental caries initiative. CSPS\u2010based drug delivery systems can effectively reconstitute the key molecules of the dentin matrix that are commonly damaged during dentinal caries or other pathologies. Additional adjustments to the mix can facilitate the development of dentin\u2010bonding agents. This review seeks to summarize the studies on CSPS on dentin hypersensitivity, and it also elaborates on possible futuristic approaches to reconstitute the dentin matrix for effective management of DH.<\/jats:p>","DOI":"10.1002\/jbm.b.35576","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:37:14Z","timestamp":1743802634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calcium Sodium Phosphosilicate in Management of Dentin Hypersensitivity and Strategies for Reconstitution of the Dentin Matrix"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-3158","authenticated-orcid":false,"given":"Ramya","family":"Ramadoss","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Saveetha Institute of Medical and Technical Sciences Saveetha Dental College and Hospitals, Saveetha University  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajashree","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Centre of Advanced Study in Crystallography &amp; Biophysics University of Madras, Guindy Campus  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.05.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2000.027010715.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520903036"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14174865"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201593"},{"key":"e_1_2_11_7_1","volume-title":"Textbook of Oral Anatomy, Physiology, Histology and Tooth Morphology","author":"Rajkumar K.","year":"2022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma8115433"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510385241"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2011.01.008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12271"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.12.052"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/B611918M"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470994603"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2013.04.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2900"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1557\/opl.2011.1114"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/B604589H"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.11.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2007.01798.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12275"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma6115335"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.03.001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.104898"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010022\u201004595\u20107"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857093318.2.129"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102842.2002.00824.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2007.04.003"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.02.045"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806\u201083242010000400002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.01.007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.05.012"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001096\u20105"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u20101038\u20104"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310008012"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.05.010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2011.06.009"},{"issue":"3","key":"e_1_2_11_38_1","first-page":"74","article-title":"A Comparative In\u00a0Vitro Study Investigating the Occlusion and Mineralization Properties of Commercial Toothpastes in a Four\u2010Day Dentin Disc Model","volume":"22","author":"Parkinson C. 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