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Regarding the clinical application of anti\u2010adhesion barriers, current products including but not limited to Interceed and chitosan\u2010based dressings have demonstrated suboptimal efficacy in practice. We developed a triple\u2010layer patch comprising: (1) a tissue\u2010adhesive inner layer of polyacrylic acid\u2010gelatin composite, (2) a mechanically dissipative intermediate layer of polyglycine, and (3) an anti\u2010adhesive external layer of polyzwitterionic polymer. In this study, we investigated the antiadhesion effect of the triple\u2010layer patch by using a uterine operation model in rats and reported that the triple\u2010layer patch can inhibit the production of tumor necrosis factor\u2010\u03b1 and transforming growth factor beta 1, upregulate tissue\u2010type plasminogen activator, and downregulate plasminogen activator inhibitor to inhibit inflammation and fibrosis. These findings substantiate that the triple\u2010layer patch may have broad applicability to prevent postoperative adhesions through inhibition of inflammatory responses and fibrotic processes, demonstrating promising translational potential in gynecological surgery.<\/jats:p>","DOI":"10.1002\/jbm.b.35600","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T13:06:31Z","timestamp":1752411991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Sandwiched Patch for Prevention of Pelvic Adhesion After Uterine Operation"],"prefix":"10.1002","volume":"113","author":[{"given":"Weiying","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minzhi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-0212","authenticated-orcid":false,"given":"Xiaozhu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"60","article-title":"Intestinal Obstruction From Adhesions: How Big Is the Problem?","volume":"72","author":"Menzies D.","year":"1990","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.12.010"},{"issue":"8","key":"e_1_2_11_5_1","article-title":"Adhesion Awareness in 2016: An Update of the National Survey of Surgeons","volume":"13","author":"Steensel S.","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612828666220422090238"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000395"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.10.018"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.53"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168781"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101637"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123274"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.12.003"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"17","article-title":"Adhesion Reduction in the Rabbit Uterine Horn Model Using an Absorbable Barrier, Tc\u20107","volume":"32","author":"Linsky C. 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