{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:35:54Z","timestamp":1755794154197,"version":"3.44.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003121","name":"Ferdowsi University of Mashhad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cancer is one of the biggest causes of death in today's world. In the field of cancer treatment, the use of natural compounds has attracted the attention of researchers. A variety of nanoparticles, including zinc oxide nanoparticles, represent a widely utilized therapeutic approach today due to their exceptional biocompatibility and safety profile. In this study, ellagic acid, which is a natural polyphenolic compound, was used together with synthesized zinc oxide nanoparticles. The loading of ellagic acid in zinc oxide nanoparticles was confirmed by FT\u2010IR and XRD methods. Examination of the viability of A549 cancer cells showed that the cytotoxicity of nano drug Ellagic acid\u2010Zno nanoparticle (EAN) is more than that of ellagic acid alone. The percentage of reactive oxygen species (ROS) produced by EAN was higher than that of ellagic acid. Apoptosis was observed in the treated cells by acridine\u2010orange\u2010ethidium\u2010bromide staining. Investigating the cell migration of EAN caused a decrease in cell migration. Based on the research, suggested that EAN can be used as multifunctional nanomedicine nanoparticles.<\/jats:p>","DOI":"10.1002\/jbm.b.35604","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T06:58:54Z","timestamp":1753081134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ellagic Acid\u2010Zinc Oxide Nanoparticles Show Antioxidant, Antibacterial Activities and Induce Apoptosis in Lung Cancer <scp>A549<\/scp> Cells"],"prefix":"10.1002","volume":"113","author":[{"given":"Farkhondeh","family":"Ghoncheh\u2010Moghadam","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science, Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-0595","authenticated-orcid":false,"given":"Ahmad","family":"Asoodeh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Ferdowsi University of Mashhad  Mashhad Iran"},{"name":"Cellular and Molecular Research Group Institute of Biotechnology, Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Vaezi\u2010Kakhki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002142.pub3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1342951"},{"key":"e_1_2_9_4_1","article-title":"Management of Small\u2010Cell Lung Cancer: Incremental Changes but Hope for the Future","volume":"22","author":"Hann C. 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