{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:14:47Z","timestamp":1754144087414,"version":"3.41.2"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aim of this study is to assess the effect of the timing of adjustment on the fatigue flexural behavior and surface characteristics of lithium disilicate\u2010based ceramics. Discs (\u00d8\u2009=\u200915 and 1.2\u2009mm thickness) of four lithium disilicate\u2010based ceramics (IPS e.max CAD, Ivoclar AG; Rosetta SM, HASS Corp; T\u2010Lithium, Shenzhen Upcera Dental Technology Co Ltd; Goozir, Shenzhen Yurucheng Dental Materials Co) were obtained and randomly allocated into three groups based on the timing of adjustment factor: CTRL\u2014directly crystallized without any additional treatment; PRE\u2014subjected to adjustment precrystallization; POST\u2014adjusted postcrystallization. The specimens underwent cyclic fatigue biaxial piston\u2010on\u2010three\u2010balls flexural testing (<jats:italic>n<\/jats:italic>\u2009=\u200910; 20\u2009Hz frequency, 10,000\u2009cycles per step, initial stress of 100\u2009MPa, and step\u2010size of 25\u2009MPa). Fatigue flexural strength (FFS) and the number of cycles for fatigue failure (CFF) were recorded and submitted to factorial (two\u2010way analysis of variance [ANOVA]), survival (Kaplan\u2013Meier and Mantel\u2013Cox tests) and Weibull analysis. Surface roughness data were collected and submitted to two\u2010way ANOVA and Tukey's posthoc tests. Fractographic and topographic features were descriptively and qualitatively analyzed. Both the adjustment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>F<\/jats:italic>\u2009=\u200949.18) and material (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>F<\/jats:italic>\u2009=\u200911.99) factors showed a statistically significant impact on the FFS and CFF, as did their interaction (<jats:italic>p<\/jats:italic>\u2009=\u20090.03 and <jats:italic>F<\/jats:italic>\u2009=\u20092.51), indicating higher values for the CTRL and PRE groups compared to the POST group, and for the T\u2010LITHIUM, EMAX, and GOOZIR materials compared to ROSETTA. Regarding the Weibull modulus, all groups showed similar statistical values. Surface roughness was also influenced by both factors (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05\u2014PRE &gt; POST &gt; CTRL). ROSETTA exhibited higher Ra values than EMAX and higher Rz values than both EMAX and TALMAX. Fractures always originated at surface defects in the tensile stress concentration region. Topographic features revealed prominent scratches in the PRE groups due to adjustments, smoother scratches in the POST groups, and polishing scratches in the CTRL groups. Consequently, while precrystallization adjustment increases the roughness of lithium disilicate\u2010based ceramics, it does not affect their fatigue behavior. Meanwhile, postcrystallization adjustment deleteriously affects the flexural fatigue strength. Thus, if needed, adjustments should be made precrystallization of lithium disilicate\u2010based ceramics. Also, different lithium disilicate\u2010based ceramics exhibit varying fatigue behaviors; in this study, Rosetta SM showed reduced properties compared to T\u2010Lithium CAD, IPS e.max CAD, and Goozir Lithium Disilicate.<\/jats:p>","DOI":"10.1002\/jbm.b.35608","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:59:24Z","timestamp":1750658364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing the Effect of Precrystallization or Postcrystallization Adjustments on Fatigue Behavior of Lithium Disilicate\u2010Based Ceramics"],"prefix":"10.1002","volume":"113","author":[{"given":"Abdel Rahim Mohamad Abdel Salam","family":"Suleiman","sequence":"first","affiliation":[{"name":"MSciD Post\u2010Graduate Program in Health and Life Sciences Franciscan University  Santa Maria Rio Grande do Sul State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Freitas Brum","family":"Souza","sequence":"additional","affiliation":[{"name":"MSciD and PhD Post\u2010Graduate Program in Oral Science, Faculty of Dentistry Federal University of Santa Maria (UFSM)  Santa Maria Rio Grande do Sul State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Felipe","family":"Wandscher","sequence":"additional","affiliation":[{"name":"School of Dentistry National Community Schools Campaig (CNEC)  Santo \u00c2ngelo Rio Grande do Sul State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Kalil Rocha","family":"Pereira","sequence":"additional","affiliation":[{"name":"MSciD and PhD Post\u2010Graduate Program in Oral Science, Faculty of Dentistry Federal University of Santa Maria (UFSM)  Santa Maria Rio Grande do Sul State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovito Adiel","family":"Skupien","sequence":"additional","affiliation":[{"name":"MSciD Post\u2010Graduate Program in Health and Life Sciences Franciscan University  Santa Maria Rio Grande do Sul State Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2021.12.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2024.03.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2017.06.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.378"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518779759"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12531"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2020.08.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2021.03.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2019.05.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12864"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2014.07.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010019\u20100838\u2010x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104833"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2021.02.031"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.06.028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2018.01.030"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2013.10.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2341\/19\u2010069\u2010L"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2019.02.012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.13938"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.07.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.03.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.07.019"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102020.vol34.0004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2013.38.3.134"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2018.03.024"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2017.09.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2021.09.034"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2023.05.007"},{"volume-title":"ISO 6872. 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