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Among emerging options, Nitinol has gained significant interest due to its unique combination of shape memory effect, superelasticity, and mechanical compatibility with bone tissue. These characteristics make it a promising candidate for spinal implants that support minimally invasive surgery and motion preservation. This review offers a comprehensive overview of Nitinol's clinical applications in orthopedics, with a particular focus on spinal procedures. It explores key material properties, device types, and performance benefits, including reduced stress shielding and improved implant\u2010tissue integration. A wide range of Nitinol\u2010based devices such as screws, plates and rods, nails, artificial discs, staples, and dynamic systems are discussed alongside clinical outcomes and case studies. Emerging directions such as additive manufacturing for patient\u2010specific implants, and smart Nitinol systems with integrated sensing or actuation capabilities are discussed. In addition, challenges in thermal control, manufacturing reproducibility, and evolving regulatory standards are addressed. By synthesizing current advancements and unmet needs, this review highlights the clinical potential of Nitinol implants and outlines future directions for their safe, effective, and scalable integration into orthopedic practice.<\/jats:p>","DOI":"10.1002\/jbm.b.35615","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T03:02:14Z","timestamp":1751511734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nitinol in Orthopedic Applications: Clinical Insights, Performance Challenges, and Future Directions"],"prefix":"10.1002","volume":"113","author":[{"given":"Niyou","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veluru Jagadeesh","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namith","family":"Rangaswamy","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Jian","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"K","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Thomas Patrick Decourcy","family":"Hallinan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil Kumar","family":"A","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-5031","authenticated-orcid":false,"given":"Naresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"},{"name":"National University Spine Institute, Department of Orthopaedic Surgery National University Hospital, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/rams-2023-0148"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214726"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.202201189"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-022-00182-x"},{"key":"e_1_2_9_6_1","volume-title":"An Investigation on Low\u2010Elastic\u2010Modulus Metallic Orthopedic Implants","author":"Niyou W.","year":"2021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40898-016-0001-2"},{"key":"e_1_2_9_8_1","first-page":"135","volume-title":"Intelligence\u2010Based Spine Care Model: A New Era of Research and Clinical Decision\u2010Making","author":"Mallow G. 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