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The synthesis conditions of CGA\u2010AgNPs, including reactant ratio, pH, temperature, and reaction time, were optimized. The synthesized CGA\u2010functionalized AgNPs were characterized by ultraviolet\u2013visible (UV\u2013Vis) spectroscopy, X\u2010ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X\u2010ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). TEM imaging results indicated that CGA\u2010AgNPs were spherical nanoparticles with an average diameter of 36.70\u2009\u00b1\u20090.65\u2009nm. FTIR spectroscopy results confirmed that CGA was covered on the surface of AgNPs. XPS results indicated that the surface of nanoparticles was made up of Ag atoms. The inhibitory activity of CGA\u2010AgNPs against <jats:styled-content style=\"fixed-case\"><jats:italic>Candida albicans<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>C. albicans<\/jats:italic><\/jats:styled-content>), <jats:italic>Acinetobacter baumanniiand<\/jats:italic> (<jats:styled-content style=\"fixed-case\"><jats:italic>A. baumannii<\/jats:italic><\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>S. aureus<\/jats:italic><\/jats:styled-content>) was measured and evaluated by the inhibition circle method and the minimum inhibitory concentration. The synthesized CGA\u2010AgNPs under optimal conditions indicated good antibacterial activity against <jats:italic><jats:styled-content style=\"fixed-case\">C. albicans<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">A. baumannii<\/jats:styled-content><\/jats:italic>, and <jats:styled-content style=\"fixed-case\"><jats:italic>S. aureus<\/jats:italic><\/jats:styled-content> with MIC values of 36.95\u2009\u00b1\u20090.22\u2009\u03bcg\/mL and MBC values of 73.90\u2009\u00b1\u20090.22\u2009\u03bcg\/mL. In summary, this study provides a facile and green synthesis method to prepare CGA\u2010AgNPs with excellent antibacterial activities.<\/jats:p>","DOI":"10.1002\/jbm.b.35616","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:03:56Z","timestamp":1753189436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydrothermal Synthesis of Chlorogenic Acid\u2010Functionalized Ag Nanoparticles and Their Antibacterial Activity"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2832-9456","authenticated-orcid":false,"given":"Shengkai","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Forest Plant Ecology, Ministry of Education Northeast Forestry University  Harbin China"},{"name":"College of Chemistry, Chemical Engineering and Resource Utilization Northeast Forestry University  Harbin China"},{"name":"Engineering Research 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