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The conduit incorporated fibrin and lycopene\u2010chitosan nanoparticles (Lyco\u2010CNPs) optimized for enhanced stability and drug delivery (diameter: 163\u2009\u00b1\u20096\u2009nm; zeta potential: \u22129.3\u2009mV), addressing limitations of prior formulations. Key structural and mechanical properties included a fiber diameter of 251\u2009\u00b1\u200922\u2009nm, tensile strength of 5.86\u2009\u00b1\u20090.98\u2009MPa, Young's modulus of 1.68\u2009\u00b1\u20090.25\u2009MPa, and pore diameter of 21.8\u2009nm, ensuring robustness and nutrient diffusion. In\u00a0vitro studies confirmed a dose\u2010dependent increase in Schwann cell proliferation via MTT assay with the addition of lycopene nanoparticles (NL). In a 10\u2010mm sciatic nerve defect model in rats, the PLGA\u2010CNT\u2010nanoLyco conduit seeded with SCs demonstrated superior regeneration, evidenced by 35.31% higher myelinated nerve density compared to controls. Histopathological (hematoxylin\u2013eosin\/Luxol fast blue) and walking\u2010footprint analysis confirmed enhanced axonal alignment and remyelination. These results highlight the conduit's dual functionality as a structural scaffold and bioactive delivery system for nerve repair.<\/jats:p>","DOI":"10.1002\/jbm.b.35643","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T11:58:04Z","timestamp":1756123084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sciatic Nerve Regeneration in Rat Model With <scp>PLGA<\/scp>\u2010<scp>MWCNT<\/scp> Conduit Loaded by Fibrin Hydrogel Containing Nanolycopene and Schwann Cells"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-2081","authenticated-orcid":false,"given":"Jafar","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine Tehran University of Medical Sciences  Tehran 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