{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:41Z","timestamp":1789647221661,"version":"4.0.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In an effort to improve bone response, predictably regenerate lost tissue, and provide an anatomically pleasing ridge contour for biomechanically favorable and prosthetically driven implant placement, guided bone regeneration (GBR) procedures have been indicated. This study provides the first direct in\u00a0vivo comparison of the biocompatibility of an experimental porcine\u2010derived collagen membrane (CMI, Regenity Biosciences, Paramus, NJ, USA) and a commercially available bovine\u2010derived collagen membrane (CopiOs, ZimVie, Palm Beach Gardens, FL, USA) in a\n                    <jats:italic>beagle<\/jats:italic>\n                    mandibular model for the purposes of GBR. Four bilateral defects of 10\u2009mm\u2009\u00d7\u200910\u2009mm through the mandibular thickness were placed in each of\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916 adult\n                    <jats:italic>beagle<\/jats:italic>\n                    dogs. Defects were filled with a deproteinized porcine\u2010derived particulate graft and were covered either with CMI or CopiOs to allow compartmentalized healing. Animals were euthanized after 4, 8, 12, or 16\u2009weeks post\u2010operatively (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094\n                    <jats:italic>beagles<\/jats:italic>\n                    \/time point). Bone regenerative capacity, graft, and soft tissue presence were evaluated by histomorphometric and microtomographic analyses. Outcome variables were compared using a mixed model analysis with fixed factor variables of time and material. Qualitatively, no histomorphological differences in healing were observed between the membrane groups at any time point. Histomorphometrically, CMI and CopiOs presented statistically significant differences in bone (mean\u2009\u00b1\u2009SD: 38.27%\u2009\u00b1\u200915.20 vs. 17.43%\u2009\u00b1\u200915.49, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) and soft tissue presence (mean\u2009\u00b1\u2009SD: 50.88%\u2009\u00b1\u200911.83 vs. 68.21%\u2009\u00b1\u200916.98, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026) at 8\u2009weeks. These results might influence treatment timing in clinical practice, by enabling early implant placement or shorter healing intervals. No significant differences were detected in these parameters at any other healing time point (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). CMI and CopiOs showed no signs of adverse immune response and led to similar trends in bone regeneration after 16\u2009weeks of permitted healing. Both membranes minimized soft tissue infiltration and maintained defect stability over the observed healing periods without adverse events such as inflammation and\/or foreign body reaction.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35651","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:55:34Z","timestamp":1758534934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Bovine and Porcine Collagen Membranes for Potential Applications in Guided Bone Regeneration: An In\u00a0Vivo Pre\u2010Clinical Evaluation"],"prefix":"10.1002","volume":"113","author":[{"given":"Vasudev Vivekanand","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute (BioNIUM), University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Arthur Kawase De Queiroz","family":"Goncalves","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Mirsky","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris R. L.","family":"Arakelians","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmara T. P.","family":"Bergamo","sequence":"additional","affiliation":[{"name":"Biomaterials and Regenerative Biology Division NYU College of Dentistry  New York New York USA"},{"name":"Department of Prosthodontics NYU College of Dentistry  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Torroni","sequence":"additional","affiliation":[{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Boczar","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute (BioNIUM), University of Miami  Miami Florida USA"},{"name":"DeWitt Daughtry Family Department of Surgery, Division of Plastic Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"additional","affiliation":[{"name":"Biomaterials and Regenerative Biology Division NYU College of Dentistry  New York New York USA"},{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery New York University Grossman School of Medicine  New York New York USA"},{"name":"Department of Oral and Maxillofacial Surgery NYU College of Dentistry  New York New York USA"},{"name":"Department of Biomedical Engineering NYU Tandon School of Engineering  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.414"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12364"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00642.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2008.01246.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2019.01.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010016\u20100267\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35299"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5461"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906\u20106713.2003.03304.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u201010\u201081"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000707"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2012.12.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090075"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2012.04.022"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314987"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.03.016"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16206633"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.921576"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13068"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10731199309117651"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201100294"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2018\u2010088"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548\u20101336(2001)027"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.078"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_10_28_1","first-page":"265","article-title":"Collagen in Tendon, Ligament, and Bone Healing. A Current Review","volume":"318","author":"Liu S. H.","year":"1995","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010008\u20100087\u2010y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.215"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305777101"},{"key":"e_1_2_10_32_1","first-page":"40","article-title":"The Tutoplast Process: A Review of Efficacy","volume":"17","author":"Schoepf C.","year":"2008","journal-title":"Zimmer Dental"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9110949"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-14-00274"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1443280"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.14402\/jkamprs.2014.36.6.239"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8828194"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13030786"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.04.015"},{"key":"e_1_2_10_40_1","unstructured":"\u201cCopios Pericardium Membrane: ZimVie \u201daccessed August 14 2025 https:\/\/eservices.zimviedental.com\/product\/copios\u2010pericardium\u2010membrane\/01t5f000003zYb8AAE."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132344"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.05.028"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb16080281"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13665"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12469"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.35651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:59:02Z","timestamp":1761663542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.35651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jbm.b.35651"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.35651","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e35651"}}