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This study focuses on the urgent development of materials aimed at filling the implant\u2010bone interface and enhancing bone regeneration. Wollastonite (CaSiO\n                    <jats:sub>3<\/jats:sub>\n                    ), a calcium silicate ceramic, stands out for its superior biocompatibility and hydroxyapatite\u2010forming capability compared to phosphate\u2010based cements. The primary objective of this research is to assess the influence of different wollastonite phases and buffered solutions on the production of calcium silicate cements. Four types of cement were evaluated, varying the studied phase (\u03b1 and \u03b2\u2010wollastonite) and the activating solution ((NH\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    HPO\n                    <jats:sub>4<\/jats:sub>\n                    and K\n                    <jats:sub>2<\/jats:sub>\n                    HPO\n                    <jats:sub>4<\/jats:sub>\n                    ). Characterization techniques such as X\u2010ray powder diffraction (XRD), Fourier\u2010transform infrared spectroscopy (FT\u2010IR), Raman spectroscopy, and scanning electron microscopy (SEM) were employed to elucidate the impact of each phase and ion on material properties. Compressive strength analysis and biological tests were also conducted. The physicochemical analysis revealed that the \u03b1\u2010wollastonite phase exhibits more non\u2010bridge oxygen (NBO) bonds and silanol groups than \u03b2\u2010wollastonite, suggesting superior bioactivity. XRD, FT\u2010IR, and Raman results demonstrated that cements prepared with ammonium buffer solutions formed hydroxyapatite, enhancing compatibility with bone tissue. Compressive strength tests showed overall equivalent strengths (approximately 6\u2009MPa), except for the sample prepared with \u03b2\u2010wollastonite and potassium phosphate, which exhibited lower resistance to compression. Alkaline phosphatase data indicated that cements formed with \u03b1\u2010wollastonite phase and (NH\n                    <jats:sub>4<\/jats:sub>\n                    )2HPO\n                    <jats:sub>4<\/jats:sub>\n                    presented superior potential for bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35666","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:33:01Z","timestamp":1761125581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toward Enhanced Bone Regeneration: Investigating the Impact of Wollastonite Phases and Buffered Solutions in Calcium Silicate Cements"],"prefix":"10.1002","volume":"113","author":[{"given":"Renata Guimar\u00e3es","family":"Ribas","sequence":"first","affiliation":[{"name":"Plasma and Processes Laboratory Institute of Technology and Aeronautics  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-1581","authenticated-orcid":false,"given":"Juliani Caroline Ribeiro","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, Oral Pathology  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna Fl\u00e1via Santana","family":"dos Santos","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, Oral Pathology  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-1927","authenticated-orcid":false,"given":"Vin\u00edcius Danilo Nonato","family":"Bezzon","sequence":"additional","affiliation":[{"name":"Federal University of ABC (UFABC)  Santo Andr\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Moreira Bastos","family":"Campos","sequence":"additional","affiliation":[{"name":"Plasma and Processes Laboratory Institute of Technology and Aeronautics  S\u00e3o Jos\u00e9 dos Campos Brazil"},{"name":"Federal University of Pelotas  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Marotta Reis","family":"de Vasconcellos","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, Oral Pathology  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmar Patroc\u00ednio","family":"Thim","sequence":"additional","affiliation":[{"name":"Plasma and Processes Laboratory Institute of Technology and Aeronautics  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Appetite and Body Weight Nutrition and the Kidney","author":"Amine A. 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