{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:34Z","timestamp":1786977994728,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the structural, morphological, hydrodynamic, colloidal stability, anticancer, antibacterial, antioxidant, and hemolytic properties of Cu and Mn doped ZnS nanosheets (NSs). XRD examination indicated that the produced NSs exhibit high purity with a cubic structure. The average crystallite size was determined to be 1.66 nm for ZCMn1, 1.60\u2009nm for ZCMn2, 1.26\u2009nm for ZCMn3, and 1.39\u2009nm for ZCMn4 NSs (ZnS\u2009=\u2009ZCMn1; Zn\n                    <jats:sub>0.98<\/jats:sub>\n                    Cu\n                    <jats:sub>0.02<\/jats:sub>\n                    S\u2009=\u2009ZCMn2; Zn\n                    <jats:sub>0.97<\/jats:sub>\n                    Mn\n                    <jats:sub>0.01<\/jats:sub>\n                    Cu\n                    <jats:sub>0.02<\/jats:sub>\n                    S\u2009=\u2009ZCMn3; Zn\n                    <jats:sub>0.96<\/jats:sub>\n                    Mn\n                    <jats:sub>0.02<\/jats:sub>\n                    Cu\n                    <jats:sub>0.02<\/jats:sub>\n                    S\u2009=\u2009ZCMn4). TEM analysis showed that the synthesized NSs exhibit a crumpled nanosheet morphology with agglomerated particles. The ZCMn4 NSs displayed the smallest hydrodynamic size and the best colloidal stability. The ZCMn4 NSs also demonstrated superior antibacterial efficacy, with zones of inhibition (ZOI) measuring 14mm, 14\u2009mm, 17\u2009mm, 16\u2009mm, and 13\u2009mm for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. faecalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , respectively. Antioxidant and hemolytic activities were also evaluated, further highlighting the multifunctionality of the synthesized nanomaterials. Notably, the ZCMn4 NSs exhibited minimal hemolytic activity, with a lysis rate of only 0.33% at a dosage of 500\u2009\u03bcg\/mL. The doped and dual\u2010doped ZnS NSs exhibited strong and selective cytotoxic effects against melanoma cells while sparing normal melanocytes. Furthermore, a TUNEL assay was performed to confirm that the reduction in cell viability resulted from apoptotic cell death. These findings underscore the potential of Mn and Cu\u2010doped ZnS nanosheets as promising therapeutic nanomaterials for cancer treatment, drug delivery, MRI, and other biological applications.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.35684","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:20:09Z","timestamp":1761542409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the Multifunctionality of Cu\/Mn\u2010Doped\n                    <scp>ZnS<\/scp>\n                    Nanosheets: A Promising Material for Cancer Therapy and Advanced Antimicrobial Applications"],"prefix":"10.1002","volume":"113","author":[{"given":"S.","family":"Murugan","sequence":"first","affiliation":[{"name":"Department of Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-4295","authenticated-orcid":false,"given":"M.","family":"Ashokkumar","sequence":"additional","affiliation":[{"name":"Department of Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J. Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for General Education National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-317X","authenticated-orcid":false,"given":"Manivannan","family":"Nandhagopal","sequence":"additional","affiliation":[{"name":"Biocontrol Microbial Product Lab, Department of Microbiology, Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences  Chennai Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1415917"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40529-024-00411-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2024.11.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9984308"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43384-4"},{"key":"e_1_2_9_7_1","first-page":"109","article-title":"Review of the Efficacy of Nanoparticle\u2010Based Drug Delivery Systems for Cancer Treatment","volume":"5","author":"Elumalai K.","year":"2024","journal-title":"Bio\/Technology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2MA00814A"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002082"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.110692"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-023-02730-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2012.04.070"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/1402-4896\/ad5472"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17947"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22105"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2021.01.163"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06456"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spmi.2017.11.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68631-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.111783"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.132455"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134497"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13399-023-04078-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1159193"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113791"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/2211738507666190429113906"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11040616"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.022"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA04611C"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-06557-1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-008-9159-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mseb.2024.117837"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jics.2024.101429"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107783"},{"key":"e_1_2_9_35_1","first-page":"e67246","article-title":"Secondary Metabolites of Halobacillus sp.: Antimicrobial and Antioxidant Activity, Biological Compatibility, and Gas Chromatography\u2010Mass Spectrometry (GC\u2010MS) Analysis","volume":"16","author":"Saleem A. 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