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Conventional wound care modalities, including wound dressings, negative pressure therapy, and growth factor delivery, have demonstrated limited success, especially in the case of chronic or refractory wounds. Recently, exosome\u2010containing scaffolds have emerged as a promising strategy for regenerative medicine in chronic wound healing. Exosomes are nano\u2010sized extracellular vesicles containing various bioactive factors that can promote regeneration through their regenerative, anti\u2010inflammatory, angiogenic, and proliferative properties, which are involved in the processes of wound healing. In particular, hydrogels have been identified as a favorable platform for exosome delivery due to their excellent biocompatibility, tunable physicochemical properties, and ECM\u2010mimetic nature. This review will highlight the biology of exosomes, different strategies for the incorporation of exosomes with scaffolds, and advances in scaffold fabrication strategies with a focus on electrospinning and three\u2010dimensional bioprinting. Challenges to clinical translation, such as standardization and regulation of exosomes, and future research perspectives will also be discussed.<\/jats:p>","DOI":"10.1002\/jbm.b.70045","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:08:09Z","timestamp":1772989689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exosome\u2010Infused Scaffolding Systems in Chronic Wound Healing: Advances, Challenges, and Future Perspectives"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0537-971X","authenticated-orcid":false,"given":"Guilin","family":"Li","sequence":"first","affiliation":[{"name":"School of Nursing, Xinyang Vocational and Technical College  Xinyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Nursing, Xinyang Vocational and Technical College  Xinyang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731460"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101072"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.05.006"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14048"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0478-y"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00030"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.068"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12993"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03345-0"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002596"},{"issue":"3","key":"e_1_2_16_12_1","first-page":"384","article-title":"Stem Cell\u2010Derived Exosomes for Wound Healing: Current Status and Promising Directions","volume":"112","author":"Vu N. 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