{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:39:11Z","timestamp":1774597151530,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Placental\u2010derived biomaterials are rising in popularity for use in treating severe skin injuries due to their abundant pro\u2010healing factors which result in improved healing outcomes. Clinical use of human\u2010derived placental products, however, is limited by high costs, donor availability, and high variability (due to age, health, and genetic factors). Porcine\u2010derived placental biomaterials have structure and pro\u2010healing factors similar to human placental materials, and can be mass produced on a larger scale, with reduced variability and cost. In this study, porcine\u2010derived placental biomaterials were compared to human\u2010derived placental biomaterials in a full\u2010thickness skin defect rat model. Porcine\u2010derived placental powder (PP), porcine\u2010derived placental membrane (PM), and human\u2010derived amniotic membrane (HM) were tested and compared to no treatment in 36 rats. At 3, 7, and 14\u2009days, rats were euthanized, and defects were excised for H&amp;E and picrosirius red staining. Analyses included wound area measurement, gross inflammation and histological inflammation scoring, qualitative assessments via H&amp;E staining, and quantification of collagen in defects via picrosirius staining over the 14\u2010day healing process. No statistical differences were found between treatment groups at each timepoint for percent difference to adjacent control defect measurements including wound area, histological inflammation scoring, and collagen quantification analyses. PP treated defects had lower gross inflammation scores compared to HM at Day 3 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048). Trends observed in wound area measurements, gross and histological inflammation scores, and collagen quantification suggested that PP treated defects induced greater healing efficacy at earlier timepoints. Additionally, PP defects had more rapid and robust crust formation which may have contributed to improved healing outcomes based on reduced inflammation, improved hair follicle growth, re\u2010epithelialization, collagen formation, and protection during wound dressing changes.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70047","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:14:52Z","timestamp":1772968492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Porcine\u2010Derived Placental Powder Treatment for Skin Wound Healing in an In\u00a0Vivo Rat\u00a0Skin\u00a0Defect Model"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6206-3797","authenticated-orcid":false,"given":"Alex","family":"Bryan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Atwill","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Blass","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Sadeghianmaryan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Bumgardner","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Herff College of Engineering The University of Memphis  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/WOUND.2019.0946"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1524\u2010475X.2009.00543.X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JVAL.2017.07.007"},{"issue":"5","key":"e_1_2_11_5_1","first-page":"866","article-title":"The Costs of Burn Victim Hospital Care Around the World: A Systematic Review","volume":"50","author":"Alejandra P.","year":"2021","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u20104575(97)00007\u20109"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.12.068"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12325\u2010017\u20100478\u2010Y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305\u20104179(98)00176\u20104"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2007.08.048"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05664"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334\u2010200101000\u201000016"},{"key":"e_1_2_11_13_1","first-page":"e25","article-title":"Experience With Biobrane: Uses and Caveats for Success","volume":"9","author":"Greenwood J. 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