{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:35Z","timestamp":1786977875499,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Effective wound healing requires dressings that support tissue regeneration while combating infection, particularly from multidrug\u2010resistant (MDR) pathogens. This study developed and evaluated a multifunctional nanocomposite wound dressing composed of quail egg white (Qeg\u2010W) and gelatin (GLT) embedded with rGO\u2013ZnO\u2013Ag nanoparticles. Nanocomposite films were prepared by incorporating rGO\u2013ZnO\u2013Ag into Qeg\u2010W and applied to full\u2010thickness skin wounds in rats. Wound closure was monitored over 21\u2009days, and tissue samples were collected for histological assessment. Antimicrobial activity against MDR pathogens was evaluated using inhibition zone and MIC assays. The nanocomposite demonstrated robust antimicrobial activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    (inhibition zones 14\u201330\u2009mm; MICs 150\u2013200\u2009\u03bcg\/mL). All wounds reached complete closure by day 21; however, NP\u2010treated wounds were associated with significantly reduced scar thickness (~4.5\u2010fold vs. GLT,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), while GLT\u2013Qeg\u2010W\u2009+\u2009NP wounds showed ~2\u2010fold reduction vs. GLT\u2013Qeg\u2010W (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Histopathological evaluation indicated trends toward improved epidermal restoration and regeneration of dermal glands and hair follicles. Overall, GLT\u2013Qeg\u2010W nanocomposites embedded with rGO\u2013ZnO\u2013Ag nanoparticles exhibited strong standalone antimicrobial activity and were associated with reduced scarring and improved tissue organization. These findings suggest the potential of this sustainable, multifunctional system as a wound dressing, while highlighting the need for further studies to confirm these effects in larger cohorts.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70050","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:09:37Z","timestamp":1772996977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quail Egg White\u2013Gelatin Nanocomposite Films With\n                    <scp>rGO<\/scp>\n                    \u2013\n                    <scp>ZnO<\/scp>\n                    \u2013Ag Nanocomposite for Antimicrobial and Scar\u2010Reducing Skin Regeneration"],"prefix":"10.1002","volume":"114","author":[{"given":"Ahmed S.","family":"Matter","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Abd","family":"Elkodous","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Information Engineering Toyohashi University of Technology  Toyohashi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Tohamy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howaida","family":"Abu\u2010Ahmed","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Korittum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Kassem","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Elkhenany","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine Alexandria University  Alexandria 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