{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:39:20Z","timestamp":1774597160093,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This research focuses on creating innovative biogenic cerium oxide nanoparticles with multifunctional capabilities to improve treatment strategies for myocardial infarction and enhance cardiac care. The study specifically examined how curcumin\u2010capped silver nanoparticles (Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) influence oxidative stress resulting from isoproterenol (ISO)\u2010induced myocardial injury. A range of sophisticated characterization methods, such as UV\u2013vis spectroscopy, FTIR, TEM, and XRD, verified that the environmentally produced Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs had a cubic structure and demonstrated significant interactions with curcumin compounds. In this investigation, adult male Wistar rats were used and divided into three groups: a control group, one subjected to ISO injections, and a third group treated with Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs. After the completion of the experiments, the levels of enzymes CK\u2010MB and LDH were measured, and the expression of inflammatory markers HIF1\u03b1, TNF\u2010\u03b1, and IL\u20106 was assessed through quantitative reverse transcription PCR (qRT\u2013PCR). Histological changes in heart tissues resulting from ISO exposure were also evaluated using Hematoxylin and Eosin (H&amp;E) staining. The results revealed a significant reduction in the inflammatory markers TNF\u2010\u03b1 and IL\u20106 in the Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs treated group. This outcome validated the anti\u2010inflammatory and antioxidant effects of Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs, suggesting their protective role against cardiac injury. The study concludes that Cur@CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs help restore redox balance and reduce inflammation, suggesting their potential protective properties. Nonetheless, further investigations are warranted to clarify their effects on inflammatory responses related to myocardial infarction.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70055","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:41:52Z","timestamp":1773200512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of Green\u2010Formulated Cerium Oxide Nanoparticles for Myocardial Infarction"],"prefix":"10.1002","volume":"114","author":[{"given":"Wenxiu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology Shandong Provincial Third Hospital, Shandong University  Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-1195","authenticated-orcid":false,"given":"Shuya","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Shandong Provincial Third Hospital, Shandong University  Jinan City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"60","article-title":"An Update on Myocardial Infarction","volume":"1","author":"Fathima S. 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